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	Author	Sinisi, S.; Alimguzhin, V.; Mancini, T.; Tronci, E.; Mari, F.; Leeners, B.
	Title	Optimal Personalised Treatment Computation through In Silico Clinical Trials on Patient Digital Twins			Type	Journal Article
	Year	2020	Publication		Abbreviated Journal	Fundamenta Informaticae
	Volume	174	Issue		Pages	283-310
	Keywords	Artificial Intelligence; Virtual Physiological Human; In Silico Clinical Trials; Simulation; Personalised Medicine; In Silico Treatment Optimisation
	Abstract	In Silico Clinical Trials (ISCT), i.e. clinical experimental campaigns carried out by means of computer simulations, hold the promise to decrease time and cost for the safety and efficacy assessment of pharmacological treatments, reduce the need for animal and human testing, and enable precision medicine. In this paper we present methods and an algorithm that, by means of extensive computer simulation-based experimental campaigns (ISCT) guided by intelligent search, optimise a pharmacological treatment for an individual patient (precision medicine ). We show the effectiveness of our approach on a case study involving a real pharmacological treatment, namely the downregulation phase of a complex clinical protocol for assisted reproduction in humans.
	Address
	Corporate Author				Thesis
	Publisher	IOS Press	Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN	1875-8681	ISBN		Medium
	Area		Expedition		Conference
	Notes				Approved	no
	Call Number	MCLab @ davi @			Serial	187
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	Author	Chen, Q.M.; Finzi, A.; Mancini, T.; Melatti, I.; Tronci, E.
	Title	MILP, Pseudo-Boolean, and OMT Solvers for Optimal Fault-Tolerant Placements of Relay Nodes in Mission Critical Wireless Networks			Type	Journal Article
	Year	2020	Publication		Abbreviated Journal	Fundamenta Informaticae
	Volume	174	Issue		Pages	229-258
	Keywords
	Abstract	In critical infrastructures like airports, much care has to be devoted in protecting radio communication networks from external electromagnetic interference. Protection of such mission-critical radio communication networks is usually tackled by exploiting radiogoniometers: at least three suitably deployed radiogoniometers, and a gateway gathering information from them, permit to monitor and localise sources of electromagnetic emissions that are not supposed to be present in the monitored area. Typically, radiogoniometers are connected to the gateway through relay nodes . As a result, some degree of fault-tolerance for the network of relay nodes is essential in order to offer a reliable monitoring. On the other hand, deployment of relay nodes is typically quite expensive. As a result, we have two conflicting requirements: minimise costs while guaranteeing a given fault-tolerance. In this paper, we address the problem of computing a deployment for relay nodes that minimises the overall cost while at the same time guaranteeing proper working of the network even when some of the relay nodes (up to a given maximum number) become faulty (fault-tolerance ). We show that, by means of a computation-intensive pre-processing on a HPC infrastructure, the above optimisation problem can be encoded as a 0/1 Linear Program, becoming suitable to be approached with standard Artificial Intelligence reasoners like MILP, PB-SAT, and SMT/OMT solvers. Our problem formulation enables us to present experimental results comparing the performance of these three solving technologies on a real case study of a relay node network deployment in areas of the Leonardo da Vinci Airport in Rome, Italy.
	Address
	Corporate Author				Thesis
	Publisher	IOS Press	Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN	1875-8681	ISBN		Medium
	Area		Expedition		Conference
	Notes				Approved	no
	Call Number	MCLab @ davi @			Serial	188
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	Author	Mancini, T.; Mari, F.; Melatti, I.; Salvo, I.; Tronci, E.
	Title	An Efficient Algorithm for Network Vulnerability Analysis Under Malicious Attacks			Type	Conference Article
	Year	2018	Publication	Foundations of Intelligent Systems – 24th International Symposium, ISMIS 2018, Limassol, Cyprus, October 29-31, 2018, Proceedings	Abbreviated Journal
	Volume		Issue		Pages	302-312
	Keywords
	Abstract
	Address
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN		ISBN		Medium
	Area		Expedition		Conference
	Notes	Best Paper			Approved	no
	Call Number	MCLab @ davi @ DBLP:conf/ismis/ManciniMMST18			Serial	176
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	Author	Mancini, T.; Mari, F.; Massini, A.; Melatti, I.; Tronci, E.
	Title	SyLVaaS: System Level Formal Verification as a Service			Type	Journal Article
	Year	2016	Publication	Fundamenta Informaticae	Abbreviated Journal
	Volume	149	Issue	1-2	Pages	101-132
	Keywords
	Abstract
	Address
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN		ISBN		Medium
	Area		Expedition		Conference
	Notes				Approved	no
	Call Number	MCLab @ davi @ DBLP:journals/fuin/ManciniMMMT16			Serial	160
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	Author	Driouich, Y.; Parente, M.; Tronci, E.
	Title	Model Checking Cyber-Physical Energy Systems			Type	Conference Article
	Year	2018	Publication	Proceedings of 2017 International Renewable and Sustainable Energy Conference, IRSEC 2017	Abbreviated Journal
	Volume		Issue		Pages
	Keywords
	Abstract
	Address
	Corporate Author				Thesis
	Publisher	Institute of Electrical and Electronics Engineers Inc.	Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN		ISBN		Medium
	Area		Expedition		Conference
	Notes				Approved	no
	Call Number	MCLab @ davi @ Driouich2018			Serial	177
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	Author	Driouich, Y.; Parente, M.; Tronci, E.
	Title	A methodology for a complete simulation of Cyber-Physical Energy Systems			Type	Conference Article
	Year	2018	Publication	EESMS 2018 – Environmental, Energy, and Structural Monitoring Systems, Proceedings	Abbreviated Journal
	Volume		Issue		Pages	1-5
	Keywords
	Abstract
	Address
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN		ISBN		Medium
	Area		Expedition		Conference
	Notes				Approved	no
	Call Number	MCLab @ davi @ Driouich20181			Serial	169
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	Author	Leeners, B.; Krueger, T.; Geraedts, K.; Tronci, E.; Mancini, T.; Ille, F.; Egli, M.; Roeblitz, S.; Wunder, D.; Saleh, L.; Schippert, C.; Hengartner, M.P.
	Title	Cognitive function in association with high estradiol levels resulting from fertility treatment			Type	Journal Article
	Year	2021	Publication	Hormones and Behavior	Abbreviated Journal
	Volume	130	Issue		Pages	104951
	Keywords	Cognition, Estrogen, Estradiol, Fertility treatment, Attention, Cognitive bias
	Abstract	The putative association between hormones and cognitive performance is controversial. While there is evidence that estradiol plays a neuroprotective role, hormone treatment has not been shown to improve cognitive performance. Current research is flawed by the evaluation of combined hormonal effects throughout the menstrual cycle or in the menopausal transition. The stimulation phase of a fertility treatment offers a unique model to study the effect of estradiol on cognitive function. This quasi-experimental observational study is based on data from 44 women receiving IVF in Zurich, Switzerland. We assessed visuospatial working memory, attention, cognitive bias, and hormone levels at the beginning and at the end of the stimulation phase of ovarian superstimulation as part of a fertility treatment. In addition to inter-individual differences, we examined intra-individual change over time (within-subject effects). The substantial increases in estradiol levels resulting from fertility treatment did not relate to any considerable change in cognitive functioning. As the tests applied represent a broad variety of cognitive functions on different levels of complexity and with various brain regions involved, we can conclude that estradiol does not show a significant short-term effect on cognitive function.
	Address
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN	0018-506x	ISBN		Medium
	Area		Expedition		Conference
	Notes				Approved	no
	Call Number	MCLab @ davi @ Leeners2021104951			Serial	185
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	Author	Mancini, T.; Mari, F.; Melatti, I.; Salvo, I.; Tronci, E.; Gruber, J.; Hayes, B.; Prodanovic, M.; Elmegaard, L.
	Title	Parallel Statistical Model Checking for Safety Verification in Smart Grids			Type	Conference Article
	Year	2018	Publication	2018 IEEE International Conference on Communications, Control, and Computing Technologies for Smart Grids (SmartGridComm)	Abbreviated Journal
	Volume		Issue		Pages	1-6
	Keywords
	Abstract
	Address
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN		ISBN		Medium
	Area		Expedition		Conference
	Notes				Approved	no
	Call Number	MCLab @ davi @ mancini-etal:2018:smartgridcomm			Serial	170
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	Author	Mancini, T.; Mari, F.; Massini, A.; Melatti, I.; Tronci, E.
	Title	Anytime system level verification via parallel random exhaustive hardware in the loop simulation			Type	Journal Article
	Year	2016	Publication	Microprocessors and Microsystems	Abbreviated Journal
	Volume	41	Issue		Pages	12-28
	Keywords	Model Checking of Hybrid Systems; Model checking driven simulation; Hardware in the loop simulation
	Abstract	Abstract System level verification of cyber-physical systems has the goal of verifying that the whole (i.e., software + hardware) system meets the given specifications. Model checkers for hybrid systems cannot handle system level verification of actual systems. Thus, Hardware In the Loop Simulation (HILS) is currently the main workhorse for system level verification. By using model checking driven exhaustive HILS, System Level Formal Verification (SLFV) can be effectively carried out for actual systems. We present a parallel random exhaustive HILS based model checker for hybrid systems that, by simulating all operational scenarios exactly once in a uniform random order, is able to provide, at any time during the verification process, an upper bound to the probability that the System Under Verification exhibits an error in a yet-to-be-simulated scenario (Omission Probability). We show effectiveness of the proposed approach by presenting experimental results on SLFV of the Inverted Pendulum on a Cart and the Fuel Control System examples in the Simulink distribution. To the best of our knowledge, no previously published model checker can exhaustively verify hybrid systems of such a size and provide at any time an upper bound to the Omission Probability.
	Address
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN	0141-9331	ISBN		Medium
	Area		Expedition		Conference
	Notes				Approved	no
	Call Number	MCLab @ davi @ Mancini201612			Serial	155
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	Author	Mancini, T.; Mari, F.; Massini, A.; Melatti, I.; Tronci, E.
	Title	On Checking Equivalence of Simulation Scripts			Type	Journal Article
	Year	2021	Publication	Journal of Logical and Algebraic Methods in Programming	Abbreviated Journal
	Volume		Issue		Pages	100640
	Keywords	Formal verification, Simulation based formal verification, Formal Verification of cyber-physical systems, System-level formal verification
	Abstract	To support Model Based Design of Cyber-Physical Systems (CPSs) many simulation based approaches to System Level Formal Verification (SLFV) have been devised. Basically, these are Bounded Model Checking approaches (since simulation horizon is of course bounded) relying on simulators to compute the system dynamics and thereby verify the given system properties. The main obstacle to simulation based SLFV is the large number of simulation scenarios to be considered and thus the huge amount of simulation time needed to complete the verification task. To save on computation time, simulation based SLFV approaches exploit the capability of simulators to save and restore simulation states. Essentially, such a time saving is obtained by optimising the simulation script defining the simulation activity needed to carry out the verification task. Although such approaches aim to (bounded) formal verification, as a matter of fact, the proof of correctness of the methods to optimise simulation scripts basically relies on an intuitive semantics for simulation scripting languages. This hampers the possibility of formally showing that the optimisations introduced to speed up the simulation activity do not actually omit checking of relevant behaviours for the system under verification. The aim of this paper is to fill the above gap by presenting an operational semantics for simulation scripting languages and by proving soundness and completeness properties for it. This, in turn, enables formal proofs of equivalence between unoptimised and optimised simulation scripts.
	Address
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN	2352-2208	ISBN		Medium
	Area		Expedition		Conference
	Notes				Approved	no
	Call Number	MCLab @ davi @ Mancini2021100640			Serial	183
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