| Records |
| Author |
Mari, Federico; Melatti, Igor; Tronci, Enrico; Finzi, Alberto |
| Title |
A multi-hop advertising discovery and delivering protocol for multi administrative domain MANET |
Type |
Journal Article |
| Year |
2013 |
Publication |
Mobile Information Systems |
Abbreviated Journal |
Mobile Information Systems |
| Volume |
3 |
Issue |
9 |
Pages |
261-280 |
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| Abstract |
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Thesis |
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| Publisher |
IOS Press |
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Original Title |
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Series Issue |
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Edition |
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ISSN  |
1574-017x (Print) 1875-905X (Online) |
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Expedition |
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Conference |
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| Notes |
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Approved |
no |
| Call Number |
Sapienza @ melatti @ |
Serial |
109 |
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| Author |
Sinisi, S.; Alimguzhin, V.; Mancini, T.; Tronci, E. |
| Title |
Reconciling interoperability with efficient Verification and Validation within open source simulation environments |
Type |
Journal Article |
| Year |
2021 |
Publication |
Simulation Modelling Practice and Theory |
Abbreviated Journal |
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| Volume |
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Issue |
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Pages |
102277 |
| Keywords |
Simulation, Verification and Validation, Interoperability, FMI/FMU, Model Exchange, Cyber-Physical Systems |
| Abstract |
A Cyber-Physical System (CPS) comprises physical as well as software subsystems. Simulation-based approaches are typically used to support design and Verification and Validation (V&V) of CPSs in several domains such as: aerospace, defence, automotive, smart grid and healthcare. Accordingly, many simulation-based tools are available to support CPS design. This, on one side, enables designers to choose the toolchain that best suits their needs, on the other side poses huge interoperability challenges when one needs to simulate CPSs whose subsystems have been designed and modelled using different toolchains. To overcome such an interoperability problem, in 2010 the Functional Mock-up Interface (FMI) has been proposed as an open standard to support both Model Exchange (ME) and Co-Simulation (CS) of simulation models created with different toolchains. FMI has been adopted by several modelling and simulation environments. Models adhering to such a standard are called Functional Mock-up Units (FMUs). Indeed FMUs play an essential role in defining complex CPSs through, e.g., the System Structure and Parametrization (SSP) standard. Simulation-based V&V of CPSs typically requires exploring different simulation scenarios (i.e., exogenous input sequences to the CPS under design). Many such scenarios have a shared prefix. Accordingly, to avoid simulating many times such shared prefixes, the simulator state at the end of a shared prefix is saved and then restored and used as a start state for the simulation of the next scenario. In this context, an important FMI feature is the capability to save and restore the internal FMU state on demand. This is crucial to increase efficiency of simulation-based V&V. Unfortunately, the implementation of this feature is not mandatory and it is available only within some commercial software. As a result, the interoperability enabled by the FMI standard cannot be fully exploited for V&V when using open-source simulation environments. This motivates developing such a feature for open-source CPS simulation environments. Accordingly, in this paper, we focus on JModelica, an open-source modelling and simulation environment for CPSs based on an open standard modelling language, namely Modelica. We describe how we have endowed JModelica with our open-source implementation of the FMI 2.0 functions needed to save and restore internal states of FMUs for ME. Furthermore, we present experimental results evaluating, through 934 benchmark models, correctness and efficiency of our extended JModelica. Our experimental results show that simulation-based V&V is, on average, 22 times faster with our get/set functionality than without it. |
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Edition |
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| ISSN |
1569-190x |
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Approved |
no |
| Call Number |
MCLab @ davi @ Sinisi2021102277 |
Serial |
186 |
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| Author |
Della Penna, Giuseppe; Intrigila, Benedetto; Melatti, Igor; Tronci, Enrico; Venturini Zilli, Marisa |
| Title |
Finite horizon analysis of Markov Chains with the Mur$\varphi$ verifier |
Type |
Journal Article |
| Year |
2006 |
Publication |
Int. J. Softw. Tools Technol. Transf. |
Abbreviated Journal |
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| Volume |
8 |
Issue |
4 |
Pages |
397-409 |
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| Abstract |
In this paper we present an explicit disk-based verification algorithm for Probabilistic Systems defining discrete time/finite state Markov Chains. Given a Markov Chain and an integer k (horizon), our algorithm checks whether the probability of reaching an error state in at most k steps is below a given threshold. We present an implementation of our algorithm within a suitable extension of the Mur$\varphi$ verifier. We call the resulting probabilistic model checker FHP-Mur$\varphi$ (Finite Horizon Probabilistic Mur$\varphi$). We present experimental results comparing FHP-Mur$\varphi$ with (a finite horizon subset of) PRISM, a state-of-the-art symbolic model checker for Markov Chains. Our experimental results show that FHP-Mur$\varphi$ can handle systems that are out of reach for PRISM, namely those involving arithmetic operations on the state variables (e.g. hybrid systems). |
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| Publisher |
Springer-Verlag |
Place of Publication |
Berlin, Heidelberg |
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Original Title |
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Series Title |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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| ISSN |
1433-2779 |
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Conference |
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Approved |
yes |
| Call Number |
Sapienza @ mari @ Dimtz06 |
Serial |
78 |
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| Author |
Maggioli, F.; Mancini, T.; Tronci, E. |
| Title |
SBML2Modelica: Integrating biochemical models within open-standard simulation ecosystems |
Type |
Journal Article |
| Year |
2019 |
Publication |
Bioinformatics |
Abbreviated Journal |
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| Volume |
36 |
Issue |
7 |
Pages |
2165–2172 |
| Keywords |
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| Abstract |
SBML is the most widespread language for the definition of biochemical models. Although dozens of SBML simulators are available, there is a general lack of support to the integration of SBML models within open-standard general-purpose simulation ecosystems. This hinders co-simulation and integration of SBML models within larger model networks, in order to, e.g., enable in-silico clinical trials of drugs, pharmacological protocols, or engineering artefacts such as biomedical devices against Virtual Physiological Human models.Modelica is one of the most popular existing open-standard general-purpose simulation languages, supported by many simulators. Modelica models are especially suited for the definition of complex networks of heterogeneous models from virtually all application domains. Models written in Modelica (and in 100+ other languages) can be readily exported into black-box Functional Mock-Up Units (FMUs), and seamlessly co-simulated and integrated into larger model networks within open-standard language-independent simulation ecosystems.In order to enable SBML model integration within heterogeneous model networks, we present SBML2Modelica, a software system translating SBML models into well-structured, user-intelligible, easily modifiable Modelica models. SBML2Modelica is SBML Level 3 Version 2 -compliant and succeeds on 96.47% of the SBML Test Suite Core (with a few rare, intricate, and easily avoidable combinations of constructs unsupported and cleanly signalled to the user). Our experimental campaign on 613 models from the BioModels database (with up to 5438 variables) shows that the major open-source (general-purpose) Modelica and FMU simulators achieve performance comparable to state-of-the-art specialised SBML simulators.SBML2Modelica is written in Java and is freely available for non-commercial use at https://bitbucket.org/mclab/sbml2modelica |
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Series Title |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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| ISSN |
1367-4803 |
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| Notes |
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Approved |
no |
| Call Number |
MCLab @ davi @ ref10.1093/bioinformatics/btz860 |
Serial |
179 |
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| Author |
Sinisi, S.; Alimguzhin, V.; Mancini, T.; Tronci, E.; Leeners, B. |
| Title |
Complete populations of virtual patients for in silico clinical trials |
Type |
Journal Article |
| Year |
2021 |
Publication |
Bioinformatics |
Abbreviated Journal |
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| Volume |
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Issue |
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Pages |
1-8 |
| Keywords |
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| Abstract |
Model-based approaches to safety and efficacy assessment of pharmacological drugs, treatment strategies, or medical devices (In Silico Clinical Trial, ISCT) aim to decrease time and cost for the needed experimentations, reduce animal and human testing, and enable precision medicine. Unfortunately, in presence of non-identifiable models (e.g., reaction networks), parameter estimation is not enough to generate complete populations of Virtual Patient (VPs), i.e., populations guaranteed to show the entire spectrum of model behaviours (phenotypes), thus ensuring representativeness of the trial.We present methods and software based on global search driven by statistical model checking that, starting from a (non-identifiable) quantitative model of the human physiology (plus drugs PK/PD) and suitable biological and medical knowledge elicited from experts, compute a population of VPs whose behaviours are representative of the whole spectrum of phenotypes entailed by the model (completeness) and pairwise distinguishable according to user-provided criteria. This enables full granularity control on the size of the population to employ in an ISCT, guaranteeing representativeness while avoiding over-representation of behaviours.We proved the effectiveness of our algorithm on a non-identifiable ODE-based model of the female Hypothalamic-Pituitary-Gonadal axis, by generating a population of 4 830 264 VPs stratified into 7 levels (at different granularity of behaviours), and assessed its representativeness against 86 retrospective health records from Pfizer, Hannover Medical School and University Hospital of Lausanne. The datasets are respectively covered by our VPs within Average Normalised Mean Absolute Error of 15%, 20%, and 35% (90% of the latter dataset is covered within 20% error). |
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Series Issue |
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Edition |
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| ISSN |
1367-4803 |
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Expedition |
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Conference |
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| Notes |
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Approved |
no |
| Call Number |
MCLab @ davi @ ref10.1093/bioinformatics/btaa1026 |
Serial |
182 |
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| Author |
Mari, Federico; Melatti, Igor; Salvo, Ivano; Tronci, Enrico |
| Title |
Model Based Synthesis of Control Software from System Level Formal Specifications |
Type |
Journal Article |
| Year |
2014 |
Publication |
ACM TRANSACTIONS ON SOFTWARE ENGINEERING AND METHODOLOGY |
Abbreviated Journal |
ACM TRANSACTIONS ON SOFTWARE ENGINEERING AND METHODOLOGY |
| Volume |
23 |
Issue |
1 |
Pages |
Article 6 |
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| Abstract |
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Thesis |
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| Publisher |
ACM |
Place of Publication |
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Series Title |
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Abbreviated Series Title |
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Edition |
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| ISSN |
1049-331X |
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Approved |
no |
| Call Number |
Sapienza @ melatti @ |
Serial |
110 |
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| Author |
Della Penna, Giuseppe; Intrigila, Benedetto; Magazzeni, Daniele; Melatti, Igor; Tronci, Enrico |
| Title |
CGMurphi: Automatic synthesis of numerical controllers for nonlinear hybrid systems |
Type |
Journal Article |
| Year |
2013 |
Publication |
European Journal of Control |
Abbreviated Journal |
European Journal of Control |
| Volume |
19 |
Issue |
1 |
Pages |
14-36 |
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| Publisher |
Elsevier North-Holland, Inc. |
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Series Title |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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| ISSN |
0947-3580 |
ISBN |
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Conference |
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Approved |
no |
| Call Number |
Sapienza @ melatti @ |
Serial |
114 |
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| Author |
Alimguzhin, Vadim; Mari, Federico; Melatti, Igor; Salvo, Ivano; Tronci, Enrico |
| Title |
On-the-Fly Control Software Synthesis |
Type |
Conference Article |
| Year |
2013 |
Publication |
Proceedings of International SPIN Symposium on Model Checking of Software (SPIN 2013) |
Abbreviated Journal |
International SPIN Symposium on Model Checking of Software |
| Volume |
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Issue |
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Pages |
61-80 |
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| Publisher |
Springer - Verlag |
Place of Publication |
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Original Title |
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Series Title |
Lecture Notes in Computer Science |
Abbreviated Series Title |
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| Series Volume |
7976 |
Series Issue |
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Edition |
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| ISSN |
0302-9743 |
ISBN |
978-3-642-39175-0 |
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Approved |
yes |
| Call Number |
Sapienza @ melatti @ |
Serial |
111 |
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| Author |
Alimguzhin, Vadim; Mari, Federico; Melatti, Igor; Salvo, Ivano; Tronci, Enrico |
| Title |
A Map-Reduce Parallel Approach to Automatic Synthesis of Control Software |
Type |
Conference Article |
| Year |
2013 |
Publication |
Proc. of International SPIN Symposium on Model Checking of Software (SPIN 2013) |
Abbreviated Journal |
International SPIN Symposium on Model Checking of Software |
| Volume |
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Issue |
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Pages |
43-60 |
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| Publisher |
Springer - Verlag |
Place of Publication |
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Original Title |
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Series Title |
Lecture Notes in Computer Science |
Abbreviated Series Title |
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| Series Volume |
7976 |
Series Issue |
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Edition |
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| ISSN |
0302-9743 |
ISBN |
978-3-642-39175-0 |
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Approved |
no |
| Call Number |
Sapienza @ melatti @ |
Serial |
112 |
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| Author |
Mancini, Toni; Mari, Federico; Massini, Annalisa; Melatti, Igor; Merli, Fabio; Tronci, Enrico |
| Title |
System Level Formal Verification via Model Checking Driven Simulation |
Type |
Conference Article |
| Year |
2013 |
Publication |
Proceedings of the 25th International Conference on Computer Aided Verification. July 13-19, 2013, Saint Petersburg, Russia |
Abbreviated Journal |
CAV 2013 |
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Issue |
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Pages |
296-312 |
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| Publisher |
Springer - Verlag |
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Series Title |
Lecture Notes in Computer Science |
Abbreviated Series Title |
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| Series Volume |
8044 |
Series Issue |
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Edition |
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| ISSN |
0302-9743 |
ISBN |
978-3-642-39798-1 |
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Conference |
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Approved |
yes |
| Call Number |
Sapienza @ mari @ |
Serial |
113 |
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