| Records |
| Author |
Fischer, S.; Ehrig, R.; Schaefer, S.; Tronci, E.; Mancini, T.; Egli, M.; Ille, F.; Krueger, T.H.C.; Leeners, B.; Roeblitz, S. |
| Title |
Mathematical Modeling and Simulation Provides Evidence for New Strategies of Ovarian Stimulation |
Type |
Journal Article |
| Year |
2021 |
Publication |
Frontiers in Endocrinology |
Abbreviated Journal |
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| Volume |
12 |
Issue |
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Pages |
117 |
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| Abstract |
New approaches to ovarian stimulation protocols, such as luteal start, random start or double stimulation, allow for flexibility in ovarian stimulation at different phases of the menstrual cycle. It has been proposed that the success of these methods is based on the continuous growth of multiple cohorts (“waves”) of follicles throughout the menstrual cycle which leads to the availability of ovarian follicles for ovarian controlled stimulation at several time points. Though several preliminary studies have been published, their scientific evidence has not been considered as being strong enough to integrate these results into routine clinical practice. This work aims at adding further scientific evidence about the efficiency of variable-start protocols and underpinning the theory of follicular waves by using mathematical modeling and numerical simulations. For this purpose, we have modified and coupled two previously published models, one describing the time course of hormones and one describing competitive follicular growth in a normal menstrual cycle. The coupled model is used to test ovarian stimulation protocols in silico. Simulation results show the occurrence of follicles in a wave-like manner during a normal menstrual cycle and qualitatively predict the outcome of ovarian stimulation initiated at different time points of the menstrual cycle. |
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1664-2392 |
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MCLab @ davi @ ref10.3389/fendo.2021.613048 |
Serial |
189 |
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| Author |
Melatti, I.; Mari, F.; Mancini, T.; Prodanovic, M.; Tronci, E. |
| Title |
A Two-Layer Near-Optimal Strategy for Substation Constraint Management via Home Batteries |
Type |
Journal Article |
| Year |
2021 |
Publication |
IEEE Transactions on Industrial Electronics |
Abbreviated Journal |
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| Volume |
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Issue |
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Pages |
1-1 |
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| Abstract |
Within electrical distribution networks, substation constraints management requires that aggregated power demand from residential users is kept within suitable bounds. Efficiency of substation constraints management can be measured as the reduction of constraints violations w.r.t. unmanaged demand. Home batteries hold the promise of enabling efficient and user-oblivious substation constraints management. Centralized control of home batteries would achieve optimal efficiency. However, it is hardly acceptable by users, since service providers (e.g., utilities or aggregators) would directly control batteries at user premises. Unfortunately, devising efficient hierarchical control strategies, thus overcoming the above problem, is far from easy. We present a novel two-layer control strategy for home batteries that avoids direct control of home devices by the service provider and at the same time yields near-optimal substation constraints management efficiency. Our simulation results on field data from 62 households in Denmark show that the substation constraints management efficiency achieved with our approach is at least 82% of the one obtained with a theoretical optimal centralized strategy. |
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To appear |
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no |
| Call Number |
MCLab @ davi @ ref9513535 |
Serial |
190 |
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| Author |
Mancini, T.; Melatti, I.; Tronci, E. |
| Title |
Any-horizon uniform random sampling and enumeration of constrained scenarios for simulation-based formal verification |
Type |
Journal Article |
| Year |
2021 |
Publication |
IEEE Transactions on Software Engineering |
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1-1 |
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Model-based approaches to the verification of non-terminating Cyber-Physical Systems (CPSs) usually rely on numerical simulation of the System Under Verification (SUV) model under input scenarios of possibly varying duration, chosen among those satisfying given constraints. Such constraints typically stem from requirements (or assumptions) on the SUV inputs and its operational environment as well as from the enforcement of additional conditions aiming at, e.g., prioritising the (often extremely long) verification activity, by, e.g., focusing on scenarios explicitly exercising selected requirements, or avoiding </i>vacuity</i> in their satisfaction. In this setting, the possibility to efficiently sample at random (with a known distribution, e.g., uniformly) within, or to efficiently enumerate (possibly in a uniformly random order) scenarios among those satisfying all the given constraints is a key enabler for the practical viability of the verification process, e.g., via simulation-based statistical model checking. Unfortunately, in case of non-trivial combinations of constraints, iterative approaches like Markovian random walks in the space of sequences of inputs in general fail in extracting scenarios according to a given distribution (e.g., uniformly), and can be very inefficient to produce at all scenarios that are both legal (with respect to SUV assumptions) and of interest (with respect to the additional constraints). For example, in our case studies, up to 91% of the scenarios generated using such iterative approaches would need to be neglected. In this article, we show how, given a set of constraints on the input scenarios succinctly defined by multiple finite memory monitors, a data structure (scenario generator) can be synthesised, from which any-horizon scenarios satisfying the input constraints can be efficiently extracted by (possibly uniform) random sampling or (randomised) enumeration. Our approach enables seamless support to virtually all simulation-based approaches to CPS verification, ranging from simple random testing to statistical model checking and formal (i.e., exhaustive) verification, when a suitable bound on the horizon or an iterative horizon enlargement strategy is defined, as in the spirit of bounded model checking. |
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| ISSN |
1939-3520 |
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To appear |
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no |
| Call Number |
MCLab @ davi @ ref9527998 |
Serial |
191 |
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| Author |
Pugliese, Rosario; Tronci, Enrico |
| Title |
Automatic Verification of a Hydroelectric Power Plant |
Type |
Conference Article |
| Year |
1996 |
Publication |
Third International Symposium of Formal Methods Europe (FME), Co-Sponsored by IFIP WG 14.3 |
Abbreviated Journal |
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Issue |
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Pages |
425-444 |
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We analyze the specification of a hydroelectric power plant by ENEL (the Italian Electric Company). Our goal is to show that for the specification of the plant (its control system in particular) some given properties hold. We were provided with an informal specification of the plant. From such informal specification we wrote a formal specification using the CCS/Meije process algebra formalism. We defined properties using μ-calculus. Automatic verification was carried out using model checking. This was done by translating our process algebra definitions (the model) and μ-calculus formulas into BDDs. In this paper we present the informal specification of the plant, its formal specification, some of the properties we verified and experimental results. |
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Springer |
Place of Publication |
Oxford, UK |
Editor |
Gaudel, M.-C.; Woodcock, J. |
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Lecture Notes in Computer Science |
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| Series Volume |
1051 |
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3-540-60973-3 |
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Approved |
yes |
| Call Number |
Sapienza @ mari @ fme96 |
Serial |
53 |
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| Author |
Fantechi, Alessandro; Gnesi, Stefania; Mazzanti, Franco; Pugliese, Rosario; Tronci, Enrico |
| Title |
A Symbolic Model Checker for ACTL |
Type |
Conference Article |
| Year |
1998 |
Publication |
International Workshop on Current Trends in Applied Formal Method (FM-Trends) |
Abbreviated Journal |
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Issue |
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Pages |
228-242 |
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| Abstract |
We present SAM, a symbolic model checker for ACTL, the action-based version of CTL. SAM relies on implicit representations of Labeled Transition Systems (LTSs), the semantic domain for ACTL formulae, and uses symbolic manipulation algorithms. SAM has been realized by translating (networks of) LTSs and, possibly recursive, ACTL formulae into BSP (Boolean Symbolic Programming), a programming language aiming at defining computations on boolean functions, and by using the BSP interpreter to carry out computations (i.e. verifications). |
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Springer |
Place of Publication |
Boppard, Germany |
Editor |
Hutter, D.; Stephan, W.; Traverso, P.; Ullmann, M. |
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Lecture Notes in Computer Science |
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| Series Volume |
1641 |
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| ISSN |
3-540-66462-9 |
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yes |
| Call Number |
Sapienza @ mari @ fm-trends98 |
Serial |
51 |
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| Author |
Tronci, Enrico; Della Penna, Giuseppe; Intrigila, Benedetto; Venturini Zilli, Marisa |
| Title |
Exploiting Transition Locality in Automatic Verification |
Type |
Conference Article |
| Year |
2001 |
Publication |
11th IFIP WG 10.5 Advanced Research Working Conference on Correct Hardware Design and Verification Methods (CHARME) |
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Issue |
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Pages |
259-274 |
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In this paper we present an algorithm to contrast state explosion when using Explicit State Space Exploration to verify protocols. We show experimentally that protocols exhibit transition locality. We present a verification algorithm that exploits transition locality as well as an implementation of it within the Mur$\varphi$ verifier. Our algorithm is compatible with all Breadth First (BF) optimization techniques present in the Mur$\varphi$ verifier and it is by no means a substitute for any of them. In fact, since our algorithm trades space with time, it is typically most useful when one runs out of memory and has already used all other state reduction techniques present in the Mur$\varphi$ verifier. Our experimental results show that using our approach we can typically save more than 40% of RAM with an average time penalty of about 50% when using (Mur$\varphi$) bit compression and 100% when using bit compression and hash compaction. |
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Springer |
Place of Publication |
Livingston, Scotland, UK |
Editor |
Margaria, T.; Melham, T.F. |
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Series Title |
Lecture Notes in Computer Science |
Abbreviated Series Title |
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| Series Volume |
2144 |
Series Issue |
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Edition |
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| ISSN |
3-540-42541-1 |
ISBN |
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Approved |
yes |
| Call Number |
Sapienza @ mari @ charme01 |
Serial |
44 |
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| Author |
Gribaudo, Marco; Horváth, Andras; Bobbio, Andrea; Tronci, Enrico; Ciancamerla, Ester; Minichino, Michele |
| Title |
Model-Checking Based on Fluid Petri Nets for the Temperature Control System of the ICARO Co-generative Plant |
Type |
Conference Article |
| Year |
2002 |
Publication |
21st International Conference on Computer Safety, Reliability and Security (SAFECOMP) |
Abbreviated Journal |
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Issue |
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Pages |
273-283 |
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| Abstract |
The modeling and analysis of hybrid systems is a recent and challenging research area which is actually dominated by two main lines: a functional analysis based on the description of the system in terms of discrete state (hybrid) automata (whose goal is to ascertain for conformity and reachability properties), and a stochastic analysis (whose aim is to provide performance and dependability measures). This paper investigates a unifying view between formal methods and stochastic methods by proposing an analysis methodology of hybrid systems based on Fluid Petri Nets (FPN). It is shown that the same FPN model can be fed to a functional analyser for model checking as well as to a stochastic analyser for performance evaluation. We illustrate our approach and show its usefulness by applying it to a “real world†hybrid system: the temperature control system of a co-generative plant. |
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Springer |
Place of Publication |
Catania, Italy |
Editor |
Anderson, S.; Bologna, S.; Felici, M. |
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Original Title |
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Series Title |
Lecture Notes in Computer Science |
Abbreviated Series Title |
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| Series Volume |
2434 |
Series Issue |
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Edition |
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| ISSN |
3-540-44157-3 |
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Approved |
yes |
| Call Number |
Sapienza @ mari @ safecomp02 |
Serial |
42 |
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| Author |
Della Penna, Giuseppe; Intrigila, Benedetto; Tronci, Enrico; Venturini Zilli, Marisa |
| Title |
Exploiting Transition Locality in the Disk Based Mur$\varphi$ Verifier |
Type |
Conference Article |
| Year |
2002 |
Publication |
4th International Conference on Formal Methods in Computer-Aided Design (FMCAD) |
Abbreviated Journal |
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Issue |
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Pages |
202-219 |
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The main obstruction to automatic verification of Finite State Systems is the huge amount of memory required to complete the verification task (state explosion). This motivates research on distributed as well as disk based verification algorithms. In this paper we present a disk based Breadth First Explicit State Space Exploration algorithm as well as an implementation of it within the Mur$\varphi$ verifier. Our algorithm exploits transition locality (i.e. the statistical fact that most transitions lead to unvisited states or to recently visited states) to decrease disk read accesses thus reducing the time overhead due to disk usage. A disk based verification algorithm for Mur$\varphi$ has been already proposed in the literature. To measure the time speed up due to locality exploitation we compared our algorithm with such previously proposed algorithm. Our experimental results show that our disk based verification algorithm is typically more than 10 times faster than such previously proposed disk based verification algorithm. To measure the time overhead due to disk usage we compared our algorithm with RAM based verification using the (standard) Mur$\varphi$ verifier with enough memory to complete the verification task. Our experimental results show that even when using 1/10 of the RAM needed to complete verification, our disk based algorithm is only between 1.4 and 5.3 times (3 times on average) slower than (RAM) Mur$\varphi$ with enough RAM memory to complete the verification task at hand. Using our disk based Mur$\varphi$ we were able to complete verification of a protocol with about $10^9$ reachable states. This would require more than 5 gigabytes of RAM using RAM based Mur$\varphi$. |
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Springer |
Place of Publication |
Portland, OR, USA |
Editor |
Aagaard, M.; O'Leary, J.W. |
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Summary Language |
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Series Title |
Lecture Notes in Computer Science |
Abbreviated Series Title |
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| Series Volume |
2517 |
Series Issue |
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Edition |
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| ISSN |
3-540-00116-6 |
ISBN |
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Approved |
yes |
| Call Number |
Sapienza @ mari @ fmcad02 |
Serial |
41 |
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| Author |
Della Penna, Giuseppe; Intrigila, Benedetto; Melatti, Igor; Minichino, Michele; Ciancamerla, Ester; Parisse, Andrea; Tronci, Enrico; Venturini Zilli, Marisa |
| Title |
Automatic Verification of a Turbogas Control System with the Mur$\varphi$ Verifier |
Type |
Conference Article |
| Year |
2003 |
Publication |
Hybrid Systems: Computation and Control, 6th International Workshop, HSCC 2003 Prague, Czech Republic, April 3-5, 2003, Proceedings |
Abbreviated Journal |
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Issue |
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Pages |
141-155 |
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| Abstract |
Automatic analysis of Hybrid Systems poses formidable challenges both from a modeling as well as from a verification point of view. We present a case study on automatic verification of a Turbogas Control System (TCS) using an extended version of the Mur$\varphi$ verifier. TCS is the heart of ICARO, a 2MW Co-generative Electric Power Plant. For large hybrid systems, as TCS is, the modeling effort accounts for a significant part of the whole verification activity. In order to ease our modeling effort we extended the Mur$\varphi$ verifier by importing the C language long double type (finite precision real numbers) into it. We give experimental results on running our extended Mur$\varphi$ on our TCS model. For example using Mur$\varphi$ we were able to compute an admissible range of values for the variation speed of the user demand of electric power to the turbogas. |
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Springer |
Place of Publication |
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Editor |
Maler, O.; Pnueli, A. |
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Summary Language |
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Original Title |
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Series Title |
Lecture Notes in Computer Science |
Abbreviated Series Title |
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| Series Volume |
2623 |
Series Issue |
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Edition |
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| ISSN |
3-540-00913-2 |
ISBN |
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Expedition |
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Conference |
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Approved |
yes |
| Call Number |
Sapienza @ mari @ Dimmcptz03 |
Serial |
88 |
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| Author |
Ciancamerla, Ester; Minichino, Michele; Serro, Stefano; Tronci, Enrico |
| Title |
Automatic Timeliness Verification of a Public Mobile Network |
Type |
Conference Article |
| Year |
2003 |
Publication |
22nd International Conference on Computer Safety, Reliability, and Security (SAFECOMP) |
Abbreviated Journal |
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| Volume |
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Issue |
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Pages |
35-48 |
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| Abstract |
This paper deals with the automatic verification of the timeliness of Public Mobile Network (PMN), consisting of Mobile Nodes (MNs) and Base Stations (BSs). We use the Mur$\varphi$ Model Checker to verify that the waiting access time of each MN, under different PMN configurations and loads, and different inter arrival times of MNs in a BS cell, is always below a preassigned threshold. Our experimental results show that Model Checking can be successfully used to generate worst case scenarios and nicely complements probabilistic methods and simulation which are typically used for performance evaluation. |
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Thesis |
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| Publisher |
Springer |
Place of Publication |
Edinburgh, UK |
Editor |
Anderson, S.; Felici, M.; Littlewood, B. |
| Language |
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Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
Lecture Notes in Computer Science |
Abbreviated Series Title |
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| Series Volume |
2788 |
Series Issue |
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Edition |
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| ISSN |
978-3-540-20126-7 |
ISBN |
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Expedition |
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Conference |
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| Notes |
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Approved |
yes |
| Call Number |
Sapienza @ mari @ safecomp03 |
Serial |
38 |
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