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Ed Kuijpers, Luigi Carotenuto, Jean- Cristophe Malapert, Daniela Markov-Vetter, Igor Melatti, Andrea Orlandini, and Ranni Pinchuk. "Collaboration on ISS Experiment Data and Knowledge Representation." In Proc. of IAC 2012. Vol. D.5.11., 2012.
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Benedetto Intrigila, Igor Melatti, Alberto Tofani, and Guido Macchiarelli. "Computational models of myocardial endomysial collagen arrangement." Computer Methods and Programs in Biomedicine 86, no. 3 (2007): 232–244. Elsevier North-Holland, Inc.. ISSN: 0169-2607. DOI: 10.1016/j.cmpb.2007.03.004.
Abstract: Collagen extracellular matrix is one of the factors related to high passive stiffness of cardiac muscle. However, the architecture and the mechanical aspects of the cardiac collagen matrix are not completely known. In particular, endomysial collagen contribution to the passive mechanics of cardiac muscle as well as its micro anatomical arrangement is still a matter of debate. In order to investigate mechanical and structural properties of endomysial collagen, we consider two alternative computational models of some specific aspects of the cardiac muscle. These two models represent two different views of endomysial collagen distribution: (1) the traditional view and (2) a new view suggested by the data obtained from scanning electron microscopy (SEM) in NaOH macerated samples (a method for isolating collagen from the other tissue). We model the myocardial tissue as a net of spring elements representing the cardiomyocytes together with the endomysial collagen distribution. Each element is a viscous elastic spring, characterized by an elastic and a viscous constant. We connect these springs to imitate the interconnections between collagen fibers. Then we apply to the net of springs some external forces of suitable magnitude and direction, obtaining an extension of the net itself. In our setting, the ratio forces magnitude /net extension is intended to model the stress /strain ratio of a microscopical portion of the myocardial tissue. To solve the problem of the correct identification of the values of the different parameters involved, we use an artificial neural network approach. In particular, we use this technique to learn, given a distribution of external forces, the elastic constants of the springs needed to obtain a desired extension as an equilibrium position. Our experimental findings show that, in the model of collagen distribution structured according to the new view, a given stress /strain ratio (of the net of springs, in the sense specified above) is obtained with much smaller (w.r.t. the other model, corresponding to the traditional view) elasticity constants of the springs. This seems to indicate that by an appropriate structure, a given stiffness of the myocardial tissue can be obtained with endomysial collagen fibers of much smaller size.
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Toni Mancini, Enrico Tronci, Ivano Salvo, Federico Mari, Annalisa Massini, and Igor Melatti. "Computing Biological Model Parameters by Parallel Statistical Model Checking." International Work Conference on Bioinformatics and Biomedical Engineering (IWBBIO 2015) 9044 (2015): 542–554. DOI: 10.1007/978-3-319-16480-9_52.
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T. Mancini, F. Mari, A. Massini, I. Melatti, I. Salvo, S. Sinisi, E. Tronci, R. Ehrig, S. Röblitz, and B. Leeners. "Computing Personalised Treatments through In Silico Clinical Trials. A Case Study on Downregulation in Assisted Reproduction." In 25th RCRA International Workshop on “Experimental Evaluation of Algorithms for Solving Problems with Combinatorial Explosion” (RCRA 2018)., 2018. DOI: 10.29007/g864.
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Federico Mari, Igor Melatti, Ivano Salvo, and Enrico Tronci. "Control Software Visualization." In Proceedings of INFOCOMP 2012, The Second International Conference on Advanced Communications and Computation, 15–20. ThinkMind, 2012. ISSN: 978-1-61208-226-4.
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E. Tronci, T. Mancini, F. Mari, I. Melatti, I. Salvo, M. Prodanovic, J. K. Gruber, B. Hayes, and L. Elmegaard. "Demand-Aware Price Policy Synthesis and Verification Services for Smart Grids." In Proceedings of Smart Grid Communications (SmartGridComm), 2014 IEEE International Conference On., 2014. DOI: 10.1109/SmartGridComm.2014.7007745.
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Francesco Brizzolari, Igor Melatti, Enrico Tronci, and Giuseppe Della Penna. "Disk Based Software Verification via Bounded Model Checking." In APSEC '07: Proceedings of the 14th Asia-Pacific Software Engineering Conference, 358–365. Washington, DC, USA: IEEE Computer Society, 2007. ISSN: 0-7695-3057-5. DOI: 10.1109/APSEC.2007.43.
Abstract: One of the most successful approach to automatic software verification is SAT based bounded model checking (BMC). One of the main factors limiting the size of programs that can be automatically verified via BMC is the huge number of clauses that the backend SAT solver has to process. In fact, because of this, the SAT solver may easily run out of RAM. We present two disk based algorithms that can considerably decrease the number of clauses that a BMC backend SAT solver has to process in RAM. Our experimental results show that using our disk based algorithms we can automatically verify programs that are out of reach for RAM based BMC.
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Giuseppe Della Penna, Benedetto Intrigila, Igor Melatti, and Enrico Tronci. "Exploiting Hub States in Automatic Verification." In Automated Technology for Verification and Analysis: Third International Symposium, ATVA 2005, Taipei, Taiwan, October 4-7, 2005, Proceedings, edited by D.A. Peled and Y.-K. Tsay, 54–68. Lecture Notes in Computer Science 3707. Springer, 2005. ISSN: 3-540-29209-8. DOI: 10.1007/11562948_7.
Abstract: In this paper we present a new algorithm to counteract state explosion when using Explicit State Space Exploration to verify protocol-like systems. We sketch the implementation of our algorithm within the Caching Mur$\varphi$ verifier and give experimental results showing its effectiveness. We show experimentally that, when memory is a scarce resource, our algorithm improves on the time performances of Caching Mur$\varphi$ verification algorithm, saving between 16% and 68% (45% on average) in computation time.
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Giuseppe Della Penna, Benedetto Intrigila, Igor Melatti, Enrico Tronci, and Marisa Venturini Zilli. "Exploiting Transition Locality in Automatic Verification of Finite State Concurrent Systems." Sttt 6, no. 4 (2004): 320–341. DOI: 10.1007/s10009-004-0149-6.
Abstract: In this paper we show that statistical properties of the transition graph of a system to be verified can be exploited to improve memory or time performances of verification algorithms. We show experimentally that protocols exhibit transition locality. That is, with respect to levels of a breadth-first state space exploration, state transitions tend to be between states belonging to close levels of the transition graph. We support our claim by measuring transition locality for the set of protocols included in the Mur$\varphi$ verifier distribution. We present a cache-based verification algorithm that exploits transition locality to decrease memory usage and a disk-based verification algorithm that exploits transition locality to decrease disk read accesses, thus reducing the time overhead due to disk usage. Both algorithms have been implemented within the Mur$\varphi$ verifier. Our experimental results show that our cache-based algorithm can typically save more than 40% of memory with an average time penalty of about 50% when using (Mur$\varphi$) bit compression and 100% when using bit compression and hash compaction, whereas our disk-based verification algorithm is typically more than ten times faster than a previously proposed disk-based verification algorithm and, even when using 10% of the memory needed to complete verification, it is only between 40 and 530% (300% on average) slower than (RAM) Mur$\varphi$ with enough memory to complete the verification task at hand. Using just 300 MB of memory our disk-based Mur$\varphi$ was able to complete verification of a protocol with about $10^9$ reachable states. This would require more than 5 GB of memory using standard Mur$\varphi$.
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Giuseppe Della Penna, Benedetto Intrigila, Igor Melatti, Enrico Tronci, and Marisa Venturini Zilli. "Finite Horizon Analysis of Markov Chains with the Mur$\varphi$ Verifier." In Correct Hardware Design and Verification Methods, 12th IFIP WG 10.5 Advanced Research Working Conference, CHARME 2003, L'Aquila, Italy, October 21-24, 2003, Proceedings, edited by D. Geist and E. Tronci, 394–409. Lecture Notes in Computer Science 2860. Springer, 2003. ISSN: 3-540-20363-X. DOI: 10.1007/978-3-540-39724-3_34.
Abstract: In this paper we present an explicit disk based verification algorithm for Probabilistic Systems defining discrete time/finite state Markov Chains. Given a Markov Chain and an integer k (horizon), our algorithm checks whether the probability of reaching an error state in at most k steps is below a given threshold. We present an implementation of our algorithm within a suitable extension of the Mur$\varphi$ verifier. We call the resulting probabilistic model checker FHP-Mur$\varphi$ (Finite Horizon Probabilistic Mur$\varphi$). We present experimental results comparing FHP-Mur$\varphi$ with (a finite horizon subset of) PRISM, a state-of-the-art symbolic model checker for Markov Chains. Our experimental results show that FHP-Mur$\varphi$ can handle systems that are out of reach for PRISM, namely those involving arithmetic operations on the state variables (e.g. hybrid systems).
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