| Records |
| Author |
Pugliese, Rosario; Tronci, Enrico |
Title  |
Automatic Verification of a Hydroelectric Power Plant |
Type |
Conference Article |
| Year |
1996 |
Publication |
Third International Symposium of Formal Methods Europe (FME), Co-Sponsored by IFIP WG 14.3 |
Abbreviated Journal |
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| Volume |
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Issue |
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Pages |
425-444 |
| Keywords |
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| Abstract |
We analyze the specification of a hydroelectric power plant by ENEL (the Italian Electric Company). Our goal is to show that for the specification of the plant (its control system in particular) some given properties hold. We were provided with an informal specification of the plant. From such informal specification we wrote a formal specification using the CCS/Meije process algebra formalism. We defined properties using μ-calculus. Automatic verification was carried out using model checking. This was done by translating our process algebra definitions (the model) and μ-calculus formulas into BDDs. In this paper we present the informal specification of the plant, its formal specification, some of the properties we verified and experimental results. |
| Address |
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Thesis |
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| Publisher |
Springer |
Place of Publication |
Oxford, UK |
Editor |
Gaudel, M.-C.; Woodcock, J. |
| Language |
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Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
Lecture Notes in Computer Science |
Abbreviated Series Title |
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| Series Volume |
1051 |
Series Issue |
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Edition |
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| ISSN |
3-540-60973-3 |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
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| Notes |
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Approved |
yes |
| Call Number |
Sapienza @ mari @ fme96 |
Serial |
53 |
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| Author |
Della Penna, Giuseppe; Intrigila, Benedetto; Melatti, Igor; Minichino, Michele; Ciancamerla, Ester; Parisse, Andrea; Tronci, Enrico; Venturini Zilli, Marisa |
| Title |
Automatic Verification of a Turbogas Control System with the Mur$\varphi$ Verifier |
Type |
Conference Article |
| Year |
2003 |
Publication |
Hybrid Systems: Computation and Control, 6th International Workshop, HSCC 2003 Prague, Czech Republic, April 3-5, 2003, Proceedings |
Abbreviated Journal |
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| Volume |
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Issue |
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Pages |
141-155 |
| Keywords |
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| Abstract |
Automatic analysis of Hybrid Systems poses formidable challenges both from a modeling as well as from a verification point of view. We present a case study on automatic verification of a Turbogas Control System (TCS) using an extended version of the Mur$\varphi$ verifier. TCS is the heart of ICARO, a 2MW Co-generative Electric Power Plant. For large hybrid systems, as TCS is, the modeling effort accounts for a significant part of the whole verification activity. In order to ease our modeling effort we extended the Mur$\varphi$ verifier by importing the C language long double type (finite precision real numbers) into it. We give experimental results on running our extended Mur$\varphi$ on our TCS model. For example using Mur$\varphi$ we were able to compute an admissible range of values for the variation speed of the user demand of electric power to the turbogas. |
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Thesis |
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| Publisher |
Springer |
Place of Publication |
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Editor |
Maler, O.; Pnueli, A. |
| Language |
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Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
Lecture Notes in Computer Science |
Abbreviated Series Title |
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| Series Volume |
2623 |
Series Issue |
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Edition |
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| ISSN |
3-540-00913-2 |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
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| Notes |
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Approved |
yes |
| Call Number |
Sapienza @ mari @ Dimmcptz03 |
Serial |
88 |
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| Author |
Della Penna, Giuseppe; Intrigila, Benedetto; Melatti, Igor; Tronci, Enrico; Venturini Zilli, Marisa |
| Title |
Bounded Probabilistic Model Checking with the Mur$\varphi$ Verifier |
Type |
Conference Article |
| Year |
2004 |
Publication |
Formal Methods in Computer-Aided Design, 5th International Conference, FMCAD 2004, Austin, Texas, USA, November 15-17, 2004, Proceedings |
Abbreviated Journal |
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| Volume |
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Issue |
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Pages |
214-229 |
| Keywords |
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| Abstract |
In this paper we present an explicit verification algorithm for Probabilistic Systems defining discrete time/finite state Markov Chains. We restrict ourselves to verification of Bounded PCTL formulas (BPCTL), that is, PCTL formulas in which all Until operators are bounded, possibly with different bounds. This means that we consider only paths (system runs) of bounded length. Given a Markov Chain $\cal M$ and a BPCTL formula Φ, our algorithm checks if Φ is satisfied in $\cal M$. This allows to verify important properties, such as reliability in Discrete Time Hybrid Systems. We present an implementation of our algorithm within a suitable extension of the Mur$\varphi$ verifier. We call FHP-Mur$\varphi$ (Finite Horizon Probabilistic Mur$\varphi$) such extension of the Mur$\varphi$ verifier. We give experimental results comparing FHP-Mur$\varphi$ with (a finite horizon subset of) PRISM, a state-of-the-art symbolic model checker for Markov Chains. Our experimental results show that FHP-Mur$\varphi$ can effectively handle verification of BPCTL formulas for systems that are out of reach for PRISM, namely those involving arithmetic operations on the state variables (e.g. hybrid systems). |
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Thesis |
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| Publisher |
Springer |
Place of Publication |
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Editor |
Hu, A.J.; Martin, A.K. |
| Language |
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Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
Lecture Notes in Computer Science |
Abbreviated Series Title |
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| Series Volume |
3312 |
Series Issue |
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Edition |
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| ISSN |
3-540-23738-0 |
ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
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| Notes |
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Approved |
yes |
| Call Number |
Sapienza @ mari @ Dimtz04 |
Serial |
87 |
| Permanent link to this record |
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| Author |
Mari, Federico; Tronci, Enrico |
| Title |
CEGAR Based Bounded Model Checking of Discrete Time Hybrid Systems |
Type |
Conference Article |
| Year |
2007 |
Publication |
Hybrid Systems: Computation and Control (HSCC 2007) |
Abbreviated Journal |
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| Volume |
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Issue |
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Pages |
399-412 |
| Keywords |
Model Checking, Abstraction, CEGAR, SAT, Hybrid Systems, DTHS |
| Abstract |
Many hybrid systems can be conveniently modeled as Piecewise Affine Discrete Time Hybrid Systems PA-DTHS. As well known Bounded Model Checking (BMC) for such systems comes down to solve a Mixed Integer Linear Programming (MILP) feasibility problem. We present a SAT based BMC algorithm for automatic verification of PA-DTHSs. Using Counterexample Guided Abstraction Refinement (CEGAR) our algorithm gradually transforms a PA-DTHS verification problem into larger and larger SAT problems. Our experimental results show that our approach can handle PA-DTHSs that are more then 50 times larger than those that can be handled using a MILP solver. |
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Thesis |
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| Publisher |
Springer |
Place of Publication |
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Editor |
Bemporad, A.; Bicchi, A.; Buttazzo, G.C. |
| Language |
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Summary Language |
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Original Title |
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| Series Editor |
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Series Title |
Lecture Notes in Computer Science |
Abbreviated Series Title |
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| Series Volume |
4416 |
Series Issue |
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Edition |
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| ISSN |
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ISBN |
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Medium |
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| Area |
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Expedition |
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Conference |
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| Notes |
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Approved |
yes |
| Call Number |
Sapienza @ mari @ MarTro07 |
Serial |
92 |
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| Author |
Della Penna, Giuseppe; Intrigila, Benedetto; Magazzeni, Daniele; Melatti, Igor; Tronci, Enrico |
| Title |
CGMurphi: Automatic synthesis of numerical controllers for nonlinear hybrid systems |
Type |
Journal Article |
| Year |
2013 |
Publication |
European Journal of Control |
Abbreviated Journal |
European Journal of Control |
| Volume |
19 |
Issue |
1 |
Pages |
14-36 |
| Keywords |
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| Abstract |
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| Address |
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Thesis |
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| Publisher |
Elsevier North-Holland, Inc. |
Place of Publication |
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Editor |
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Summary Language |
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Original Title |
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Series Title |
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Abbreviated Series Title |
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Series Issue |
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Edition |
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| ISSN |
0947-3580 |
ISBN |
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| Notes |
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Approved |
no |
| Call Number |
Sapienza @ melatti @ |
Serial |
114 |
| Permanent link to this record |
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| Author |
Leeners, B.; Krueger, T.; Geraedts, K.; Tronci, E.; Mancini, T.; Ille, F.; Egli, M.; Roeblitz, S.; Wunder, D.; Saleh, L.; Schippert, C.; Hengartner, M.P. |
| Title |
Cognitive function in association with high estradiol levels resulting from fertility treatment |
Type |
Journal Article |
| Year |
2021 |
Publication |
Hormones and Behavior |
Abbreviated Journal |
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| Volume |
130 |
Issue |
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Pages |
104951 |
| Keywords |
Cognition, Estrogen, Estradiol, Fertility treatment, Attention, Cognitive bias |
| Abstract |
The putative association between hormones and cognitive performance is controversial. While there is evidence that estradiol plays a neuroprotective role, hormone treatment has not been shown to improve cognitive performance. Current research is flawed by the evaluation of combined hormonal effects throughout the menstrual cycle or in the menopausal transition. The stimulation phase of a fertility treatment offers a unique model to study the effect of estradiol on cognitive function. This quasi-experimental observational study is based on data from 44 women receiving IVF in Zurich, Switzerland. We assessed visuospatial working memory, attention, cognitive bias, and hormone levels at the beginning and at the end of the stimulation phase of ovarian superstimulation as part of a fertility treatment. In addition to inter-individual differences, we examined intra-individual change over time (within-subject effects). The substantial increases in estradiol levels resulting from fertility treatment did not relate to any considerable change in cognitive functioning. As the tests applied represent a broad variety of cognitive functions on different levels of complexity and with various brain regions involved, we can conclude that estradiol does not show a significant short-term effect on cognitive function. |
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Place of Publication |
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Abbreviated Series Title |
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Edition |
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| ISSN |
0018-506x |
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Approved |
no |
| Call Number |
MCLab @ davi @ Leeners2021104951 |
Serial |
185 |
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| Author |
Sinisi, S.; Alimguzhin, V.; Mancini, T.; Tronci, E.; Leeners, B. |
| Title |
Complete populations of virtual patients for in silico clinical trials |
Type |
Journal Article |
| Year |
2021 |
Publication |
Bioinformatics |
Abbreviated Journal |
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| Volume |
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Issue |
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Pages |
1-8 |
| Keywords |
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| Abstract |
Model-based approaches to safety and efficacy assessment of pharmacological drugs, treatment strategies, or medical devices (In Silico Clinical Trial, ISCT) aim to decrease time and cost for the needed experimentations, reduce animal and human testing, and enable precision medicine. Unfortunately, in presence of non-identifiable models (e.g., reaction networks), parameter estimation is not enough to generate complete populations of Virtual Patient (VPs), i.e., populations guaranteed to show the entire spectrum of model behaviours (phenotypes), thus ensuring representativeness of the trial.We present methods and software based on global search driven by statistical model checking that, starting from a (non-identifiable) quantitative model of the human physiology (plus drugs PK/PD) and suitable biological and medical knowledge elicited from experts, compute a population of VPs whose behaviours are representative of the whole spectrum of phenotypes entailed by the model (completeness) and pairwise distinguishable according to user-provided criteria. This enables full granularity control on the size of the population to employ in an ISCT, guaranteeing representativeness while avoiding over-representation of behaviours.We proved the effectiveness of our algorithm on a non-identifiable ODE-based model of the female Hypothalamic-Pituitary-Gonadal axis, by generating a population of 4 830 264 VPs stratified into 7 levels (at different granularity of behaviours), and assessed its representativeness against 86 retrospective health records from Pfizer, Hannover Medical School and University Hospital of Lausanne. The datasets are respectively covered by our VPs within Average Normalised Mean Absolute Error of 15%, 20%, and 35% (90% of the latter dataset is covered within 20% error). |
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Edition |
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| ISSN |
1367-4803 |
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no |
| Call Number |
MCLab @ davi @ ref10.1093/bioinformatics/btaa1026 |
Serial |
182 |
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| Author |
Toni Mancini; Enrico Tronci; Ivano Salvo; Federico Mari; Annalisa Massini; Igor Melatti |
| Title |
Computing Biological Model Parameters by Parallel Statistical Model Checking |
Type |
Journal Article |
| Year |
2015 |
Publication |
International Work Conference on Bioinformatics and Biomedical Engineering (IWBBIO 2015) |
Abbreviated Journal |
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| Volume |
9044 |
Issue |
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Pages |
542-554 |
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no |
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MCLab @ davi @ |
Serial |
124 |
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| Author |
Mancini, T.; Mari, F.; Massini, A.; Melatti, I.; Salvo, I.; Sinisi, S.; Tronci, E.; Ehrig, R.; Röblitz, S.; Leeners, B. |
| Title |
Computing Personalised Treatments through In Silico Clinical Trials. A Case Study on Downregulation in Assisted Reproduction |
Type |
Conference Article |
| Year |
2018 |
Publication |
25th RCRA International Workshop on “Experimental Evaluation of Algorithms for Solving Problems with Combinatorial Explosion” (RCRA 2018) |
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no |
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MCLab @ davi @ |
Serial |
175 |
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| Author |
Mari, Federico; Melatti, Igor; Salvo, Ivano; Tronci, Enrico |
| Title |
Control Software Visualization |
Type |
Conference Article |
| Year |
2012 |
Publication |
Proceedings of INFOCOMP 2012, The Second International Conference on Advanced Communications and Computation |
Abbreviated Journal |
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Issue |
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Pages |
15-20 |
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| Publisher |
ThinkMind |
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978-1-61208-226-4 |
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Approved |
yes |
| Call Number |
Sapienza @ mari @ infocomp2012 |
Serial |
100 |
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