| Records |
| Author |
Sinisi, S.; Alimguzhin, V.; Mancini, T.; Tronci, E.; Mari, F.; Leeners, B. |
| Title |
Optimal Personalised Treatment Computation through In Silico Clinical Trials on Patient Digital Twins |
Type |
Journal Article |
| Year |
2020 |
Publication |
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Abbreviated Journal |
Fundamenta Informaticae |
| Volume |
174 |
Issue |
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Pages |
283-310 |
| Keywords |
Artificial Intelligence; Virtual Physiological Human; In Silico Clinical Trials; Simulation; Personalised Medicine; In Silico Treatment Optimisation |
| Abstract |
In Silico Clinical Trials (ISCT), i.e. clinical experimental campaigns carried out by means of computer simulations, hold the promise to decrease time and cost for the safety and efficacy assessment of pharmacological treatments, reduce the need for animal and human testing, and enable precision medicine. In this paper we present methods and an algorithm that, by means of extensive computer simulation-based experimental campaigns (ISCT) guided by intelligent search, optimise a pharmacological treatment for an individual patient (precision medicine ). We show the effectiveness of our approach on a case study involving a real pharmacological treatment, namely the downregulation phase of a complex clinical protocol for assisted reproduction in humans. |
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IOS Press |
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1875-8681 |
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MCLab @ davi @ |
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187 |
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| Author |
Chen, Q.M.; Finzi, A.; Mancini, T.; Melatti, I.; Tronci, E. |
| Title |
MILP, Pseudo-Boolean, and OMT Solvers for Optimal Fault-Tolerant Placements of Relay Nodes in Mission Critical Wireless Networks |
Type |
Journal Article |
| Year |
2020 |
Publication |
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Abbreviated Journal |
Fundamenta Informaticae |
| Volume |
174 |
Issue |
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Pages |
229-258 |
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| Abstract |
In critical infrastructures like airports, much care has to be devoted in protecting radio communication networks from external electromagnetic interference. Protection of such mission-critical radio communication networks is usually tackled by exploiting radiogoniometers: at least three suitably deployed radiogoniometers, and a gateway gathering information from them, permit to monitor and localise sources of electromagnetic emissions that are not supposed to be present in the monitored area. Typically, radiogoniometers are connected to the gateway through relay nodes . As a result, some degree of fault-tolerance for the network of relay nodes is essential in order to offer a reliable monitoring. On the other hand, deployment of relay nodes is typically quite expensive. As a result, we have two conflicting requirements: minimise costs while guaranteeing a given fault-tolerance. In this paper, we address the problem of computing a deployment for relay nodes that minimises the overall cost while at the same time guaranteeing proper working of the network even when some of the relay nodes (up to a given maximum number) become faulty (fault-tolerance ). We show that, by means of a computation-intensive pre-processing on a HPC infrastructure, the above optimisation problem can be encoded as a 0/1 Linear Program, becoming suitable to be approached with standard Artificial Intelligence reasoners like MILP, PB-SAT, and SMT/OMT solvers. Our problem formulation enables us to present experimental results comparing the performance of these three solving technologies on a real case study of a relay node network deployment in areas of the Leonardo da Vinci Airport in Rome, Italy. |
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IOS Press |
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1875-8681 |
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MCLab @ davi @ |
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188 |
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| Author |
Mancini, T.; Mari, F.; Massini, A.; Melatti, I.; Tronci, E. |
| Title |
SyLVaaS: System Level Formal Verification as a Service |
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Journal Article |
| Year |
2016 |
Publication |
Fundamenta Informaticae |
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149 |
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1-2 |
Pages |
101-132 |
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MCLab @ davi @ DBLP:journals/fuin/ManciniMMMT16 |
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160 |
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| Author |
Cesta, Amedeo; Fratini, Simone; Orlandini, Andrea; Finzi, Alberto; Tronci, Enrico |
| Title |
Flexible Plan Verification: Feasibility Results |
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Journal Article |
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2011 |
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Fundamenta Informaticae |
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107 |
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2 |
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111-137 |
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yes |
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Sapienza @ mari @ fi11 |
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15 |
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| Author |
Mancini, T.; Tronci, E.; Scialanca, A.; Lanciotti, F.; Finzi, A.; Guarneri, R.; Di Pompeo, S. |
| Title |
Optimal Fault-Tolerant Placement of Relay Nodes in a Mission Critical Wireless Network |
Type |
Conference Article |
| Year |
2018 |
Publication |
25th RCRA International Workshop on “Experimental Evaluation of Algorithms for Solving Problems with Combinatorial Explosion” (RCRA 2018) |
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MCLab @ davi @ |
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174 |
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Mancini, T.; Mari, F.; Massini, A.; Melatti, I.; Salvo, I.; Sinisi, S.; Tronci, E.; Ehrig, R.; Röblitz, S.; Leeners, B. |
| Title |
Computing Personalised Treatments through In Silico Clinical Trials. A Case Study on Downregulation in Assisted Reproduction |
Type |
Conference Article |
| Year |
2018 |
Publication |
25th RCRA International Workshop on “Experimental Evaluation of Algorithms for Solving Problems with Combinatorial Explosion” (RCRA 2018) |
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MCLab @ davi @ |
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175 |
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Verzino Giovanni ; Cavaliere, Federico; Mari, Federico; Melatti, Igor; Minei, Giovanni; Salvo, Ivano; Yushtein, Yuri; Tronci, Enrico |
| Title |
Model checking driven simulation of sat procedures |
Type |
Conference Article |
| Year |
2012 |
Publication |
Proceedings of 12th International Conference on Space Operations (SpaceOps 2012) |
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International Conference on Space Operations |
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Sapienza @ melatti @ |
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117 |
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Alimguzhin, Vadim; Mari, Federico; Melatti, Igor; Salvo, Ivano; Tronci, Enrico |
| Title |
On Model Based Synthesis of Embedded Control Software |
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Conference Article |
| Year |
2012 |
Publication |
Proceedings of the 12th International Conference on Embedded Software, EMSOFT 2012, part of the Eighth Embedded Systems Week, ESWeek 2012, Tampere, Finland, October 7-12, 2012 |
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227-236 |
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ACM |
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Ahmed Jerraya and Luca P. Carloni and Florence Maraninchi and John Regehr |
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978-1-4503-1425-1 |
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Techreport version can be found at arxiv.org |
Approved |
yes |
| Call Number |
Sapienza @ mari @ emsoft12 |
Serial |
97 |
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| Author |
Mancini, T.; Massini, A.; Tronci, E. |
| Title |
Parallelization of Cycle-Based Logic Simulation |
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Journal Article |
| Year |
2017 |
Publication |
Parallel Processing Letters |
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27 |
Issue |
02 |
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MCLab @ davi @ |
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166 |
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| Author |
Piperno, Adolfo; Tronci, Enrico |
| Title |
Regular Systems of Equations in λ-calculus |
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Journal Article |
| Year |
1990 |
Publication |
Int. J. Found. Comput. Sci. |
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1 |
Issue |
3 |
Pages |
325-340 |
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Many problems arising in equational theories like Lambda-calculus and Combinatory Logic can be expressed by combinatory equations or systems of equations. However, the solvability problem for an arbitrarily given class of systems is in general undecidable. In this paper we shall focus our attention on a decidable class of systems, which will be called regular systems, and we shall analyse some classical problems and well-known properties of Lambda-calculus that can be described and solved by means of regular systems. The significance of such class will be emphasized showing that for slight extensions of it the solvability problem turns out to be undecidable. |
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yes |
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Sapienza @ mari @ ijfcs90 |
Serial |
60 |
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