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Author Ehrig, R.; Dierkes, T.; Schaefer, S.; Roeblitz, S.; Tronci, E.; Mancini, T.; Salvo, I.; Alimguzhin, V.; Mari, F.; Melatti, I.; Massini, A.; Leeners, B.; Krueger, T.H.C.; Egli, M.; Ille, F.
Title An integrative approach for model driven computation of treatments in reproductive medicine Type Conference Article
Year 2015 Publication Proceedings of the 15th International Symposium on Mathematical and Computational Biology (BIOMAT 2015), Rorkee, India Abbreviated Journal
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Call Number Sapienza @ preissler @ Ehrig_etal2015 Serial 144
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Author Alimguzhin, V.; Mari, F.; Melatti, I.; Tronci, E.; Ebeid, E.; Mikkelsen, S.A.; Jacobsen, R.H.; Gruber, J.K.; Hayes, B.; Huerta, F.; Prodanovic, M.
Title A Glimpse of SmartHG Project Test-bed and Communication Infrastructure Type Conference Article
Year 2015 Publication Digital System Design (DSD), 2015 Euromicro Conference on Abbreviated Journal
Volume Issue Pages 225-232
Keywords Batteries; Control systems; Databases; Production; Sensors; Servers; Smart grids; Grid State Estimation; Peak Shaving; Policy Robustness Verification; Price Policy Synthesis
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Call Number Sapienza @ preissler @ Alimguzhin_etal2015 Serial 127
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Author Mancini, Toni; Mari, Federico; Massini, Annalisa; Melatti, Igor; Tronci, Enrico
Title Simulator Semantics for System Level Formal Verification Type Conference Article
Year 2015 Publication Proceedings Sixth International Symposium on Games, Automata, Logics and Formal Verification (GandALF 2015), Abbreviated Journal
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Call Number MCLab @ davi @ Serial 125
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Author Toni Mancini; Enrico Tronci; Ivano Salvo; Federico Mari; Annalisa Massini; Igor Melatti
Title Computing Biological Model Parameters by Parallel Statistical Model Checking Type Journal Article
Year 2015 Publication International Work Conference on Bioinformatics and Biomedical Engineering (IWBBIO 2015) Abbreviated Journal
Volume 9044 Issue Pages 542-554
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Call Number MCLab @ davi @ Serial 124
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Author Mancini, T.; Mari, F.; Massini, A.; Melatti, I.; Tronci, E.
Title SyLVaaS: System Level Formal Verification as a Service Type Journal Article
Year 2016 Publication Fundamenta Informaticae Abbreviated Journal
Volume 149 Issue 1-2 Pages 101-132
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Call Number MCLab @ davi @ DBLP:journals/fuin/ManciniMMMT16 Serial 160
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Author Mancini, T.; Mari, F.; Melatti, I.; Salvo, I.; Tronci, E.; Gruber, J.; Hayes, B.; Prodanovic, M.; Elmegaard, L.
Title Parallel Statistical Model Checking for Safety Verification in Smart Grids Type Conference Article
Year 2018 Publication 2018 IEEE International Conference on Communications, Control, and Computing Technologies for Smart Grids (SmartGridComm) Abbreviated Journal
Volume Issue Pages 1-6
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Call Number MCLab @ davi @ mancini-etal:2018:smartgridcomm Serial 170
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Author Mancini, T.; Mari, F.; Massini, A.; Melatti, I.; Salvo, I.; Sinisi, S.; Tronci, E.; Ehrig, R.; Röblitz, S.; Leeners, B.
Title Computing Personalised Treatments through In Silico Clinical Trials. A Case Study on Downregulation in Assisted Reproduction Type Conference Article
Year 2018 Publication 25th RCRA International Workshop on “Experimental Evaluation of Algorithms for Solving Problems with Combinatorial Explosion” (RCRA 2018) Abbreviated Journal
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Call Number MCLab @ davi @ Serial 175
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Author Mancini, T.; Mari, F.; Massini, A.; Melatti, I.; Tronci, E.
Title Anytime system level verification via parallel random exhaustive hardware in the loop simulation Type Journal Article
Year 2016 Publication Microprocessors and Microsystems Abbreviated Journal
Volume 41 Issue Pages 12-28
Keywords Model Checking of Hybrid Systems; Model checking driven simulation; Hardware in the loop simulation
Abstract (up) Abstract System level verification of cyber-physical systems has the goal of verifying that the whole (i.e., software + hardware) system meets the given specifications. Model checkers for hybrid systems cannot handle system level verification of actual systems. Thus, Hardware In the Loop Simulation (HILS) is currently the main workhorse for system level verification. By using model checking driven exhaustive HILS, System Level Formal Verification (SLFV) can be effectively carried out for actual systems. We present a parallel random exhaustive HILS based model checker for hybrid systems that, by simulating all operational scenarios exactly once in a uniform random order, is able to provide, at any time during the verification process, an upper bound to the probability that the System Under Verification exhibits an error in a yet-to-be-simulated scenario (Omission Probability). We show effectiveness of the proposed approach by presenting experimental results on SLFV of the Inverted Pendulum on a Cart and the Fuel Control System examples in the Simulink distribution. To the best of our knowledge, no previously published model checker can exhaustively verify hybrid systems of such a size and provide at any time an upper bound to the Omission Probability.
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ISSN 0141-9331 ISBN Medium
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Call Number MCLab @ davi @ Mancini201612 Serial 155
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Author Della Penna, Giuseppe; Intrigila, Benedetto; Melatti, Igor; Minichino, Michele; Ciancamerla, Ester; Parisse, Andrea; Tronci, Enrico; Venturini Zilli, Marisa
Title Automatic Verification of a Turbogas Control System with the Mur$\varphi$ Verifier Type Conference Article
Year 2003 Publication Hybrid Systems: Computation and Control, 6th International Workshop, HSCC 2003 Prague, Czech Republic, April 3-5, 2003, Proceedings Abbreviated Journal
Volume Issue Pages 141-155
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Abstract (up) Automatic analysis of Hybrid Systems poses formidable challenges both from a modeling as well as from a verification point of view. We present a case study on automatic verification of a Turbogas Control System (TCS) using an extended version of the Mur$\varphi$ verifier. TCS is the heart of ICARO, a 2MW Co-generative Electric Power Plant. For large hybrid systems, as TCS is, the modeling effort accounts for a significant part of the whole verification activity. In order to ease our modeling effort we extended the Mur$\varphi$ verifier by importing the C language long double type (finite precision real numbers) into it. We give experimental results on running our extended Mur$\varphi$ on our TCS model. For example using Mur$\varphi$ we were able to compute an admissible range of values for the variation speed of the user demand of electric power to the turbogas.
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Publisher Springer Place of Publication Editor Maler, O.; Pnueli, A.
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Series Editor Series Title Lecture Notes in Computer Science Abbreviated Series Title
Series Volume 2623 Series Issue Edition
ISSN 3-540-00913-2 ISBN Medium
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Call Number Sapienza @ mari @ Dimmcptz03 Serial 88
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Author Sinisi, S.; Alimguzhin, V.; Mancini, T.; Tronci, E.; Mari, F.; Leeners, B.
Title Optimal Personalised Treatment Computation through In Silico Clinical Trials on Patient Digital Twins Type Journal Article
Year 2020 Publication Abbreviated Journal Fundamenta Informaticae
Volume 174 Issue Pages 283-310
Keywords Artificial Intelligence; Virtual Physiological Human; In Silico Clinical Trials; Simulation; Personalised Medicine; In Silico Treatment Optimisation
Abstract (up) In Silico Clinical Trials (ISCT), i.e. clinical experimental campaigns carried out by means of computer simulations, hold the promise to decrease time and cost for the safety and efficacy assessment of pharmacological treatments, reduce the need for animal and human testing, and enable precision medicine. In this paper we present methods and an algorithm that, by means of extensive computer simulation-based experimental campaigns (ISCT) guided by intelligent search, optimise a pharmacological treatment for an individual patient (precision medicine ). We show the effectiveness of our approach on a case study involving a real pharmacological treatment, namely the downregulation phase of a complex clinical protocol for assisted reproduction in humans.
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ISSN 1875-8681 ISBN Medium
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Call Number MCLab @ davi @ Serial 187
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