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Mancini, T.; Mari, F.; Massini, A.; Melatti, I.; Salvo, I.; Sinisi, S.; Tronci, E.; Ehrig, R.; Röblitz, S.; Leeners, B. |
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Computing Personalised Treatments through In Silico Clinical Trials. A Case Study on Downregulation in Assisted Reproduction |
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2018 |
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25th RCRA International Workshop on “Experimental Evaluation of Algorithms for Solving Problems with Combinatorial Explosion” (RCRA 2018) |
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MCLab @ davi @ |
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175 |
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Sinisi, S.; Alimguzhin, V.; Mancini, T.; Tronci, E.; Mari, F.; Leeners, B. |
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Title |
Optimal Personalised Treatment Computation through In Silico Clinical Trials on Patient Digital Twins |
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Journal Article |
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2020 |
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Fundamenta Informaticae |
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174 |
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283-310 |
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Artificial Intelligence; Virtual Physiological Human; In Silico Clinical Trials; Simulation; Personalised Medicine; In Silico Treatment Optimisation |
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In Silico Clinical Trials (ISCT), i.e. clinical experimental campaigns carried out by means of computer simulations, hold the promise to decrease time and cost for the safety and efficacy assessment of pharmacological treatments, reduce the need for animal and human testing, and enable precision medicine. In this paper we present methods and an algorithm that, by means of extensive computer simulation-based experimental campaigns (ISCT) guided by intelligent search, optimise a pharmacological treatment for an individual patient (precision medicine ). We show the effectiveness of our approach on a case study involving a real pharmacological treatment, namely the downregulation phase of a complex clinical protocol for assisted reproduction in humans. |
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IOS Press |
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1875-8681 |
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187 |
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Mancini, Toni; Mari, Federico; Massini, Annalisa; Melatti, Igor; Tronci, Enrico |
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Anytime System Level Verification via Random Exhaustive Hardware In The Loop Simulation |
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2014 |
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In Proceedings of 17th EuroMicro Conference on Digital System Design (DSD 2014) |
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