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Author Mancini, Toni; Mari, Federico; Massini, Annalisa; Melatti, Igor; Tronci, Enrico
Title Anytime System Level Verification via Random Exhaustive Hardware In The Loop Simulation Type Conference Article
Year 2014 Publication In Proceedings of 17th EuroMicro Conference on Digital System Design (DSD 2014) Abbreviated Journal
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Call Number (up) MCLab @ davi @ Serial 122
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Author Sinisi, S.; Alimguzhin, V.; Mancini, T.; Tronci, E.; Mari, F.; Leeners, B.
Title Optimal Personalised Treatment Computation through In Silico Clinical Trials on Patient Digital Twins Type Journal Article
Year 2020 Publication Abbreviated Journal Fundamenta Informaticae
Volume 174 Issue Pages 283-310
Keywords Artificial Intelligence; Virtual Physiological Human; In Silico Clinical Trials; Simulation; Personalised Medicine; In Silico Treatment Optimisation
Abstract In Silico Clinical Trials (ISCT), i.e. clinical experimental campaigns carried out by means of computer simulations, hold the promise to decrease time and cost for the safety and efficacy assessment of pharmacological treatments, reduce the need for animal and human testing, and enable precision medicine. In this paper we present methods and an algorithm that, by means of extensive computer simulation-based experimental campaigns (ISCT) guided by intelligent search, optimise a pharmacological treatment for an individual patient (precision medicine ). We show the effectiveness of our approach on a case study involving a real pharmacological treatment, namely the downregulation phase of a complex clinical protocol for assisted reproduction in humans.
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ISSN 1875-8681 ISBN Medium
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Call Number (up) MCLab @ davi @ Serial 187
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Author Mancini, T.; Mari, F.; Massini, A.; Melatti, I.; Salvo, I.; Sinisi, S.; Tronci, E.; Ehrig, R.; Röblitz, S.; Leeners, B.
Title Computing Personalised Treatments through In Silico Clinical Trials. A Case Study on Downregulation in Assisted Reproduction Type Conference Article
Year 2018 Publication 25th RCRA International Workshop on “Experimental Evaluation of Algorithms for Solving Problems with Combinatorial Explosion” (RCRA 2018) Abbreviated Journal
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Call Number (up) MCLab @ davi @ Serial 175
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Author Mancini, Toni; Mari, Federico; Massini, Annalisa; Melatti, Igor; Tronci, Enrico
Title SyLVaaS: System Level Formal Verification as a Service Type Conference Article
Year 2015 Publication Proceedings of the 23rd Euromicro International Conference on Parallel, Distributed and Network-based Processing (PDP 2015), special session on Formal Approaches to Parallel and Distributed Systems (4PAD) Abbreviated Journal
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Call Number (up) MCLab @ davi @ Serial 123
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Author Mancini, Toni; Mari, Federico; Massini, Annalisa; Melatti, Igor; Tronci, Enrico
Title Simulator Semantics for System Level Formal Verification Type Conference Article
Year 2015 Publication Proceedings Sixth International Symposium on Games, Automata, Logics and Formal Verification (GandALF 2015), Abbreviated Journal
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Call Number (up) MCLab @ davi @ Serial 125
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Author Toni Mancini; Enrico Tronci; Ivano Salvo; Federico Mari; Annalisa Massini; Igor Melatti
Title Computing Biological Model Parameters by Parallel Statistical Model Checking Type Journal Article
Year 2015 Publication International Work Conference on Bioinformatics and Biomedical Engineering (IWBBIO 2015) Abbreviated Journal
Volume 9044 Issue Pages 542-554
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Call Number (up) MCLab @ davi @ Serial 124
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Author Mancini, T.; Mari, F.; Melatti, I.; Salvo, I.; Tronci, E.
Title An Efficient Algorithm for Network Vulnerability Analysis Under Malicious Attacks Type Conference Article
Year 2018 Publication Foundations of Intelligent Systems – 24th International Symposium, ISMIS 2018, Limassol, Cyprus, October 29-31, 2018, Proceedings Abbreviated Journal
Volume Issue Pages 302-312
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Call Number (up) MCLab @ davi @ DBLP:conf/ismis/ManciniMMST18 Serial 176
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Author Mancini, T.; Mari, F.; Massini, A.; Melatti, I.; Tronci, E.
Title SyLVaaS: System Level Formal Verification as a Service Type Journal Article
Year 2016 Publication Fundamenta Informaticae Abbreviated Journal
Volume 149 Issue 1-2 Pages 101-132
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Call Number (up) MCLab @ davi @ DBLP:journals/fuin/ManciniMMMT16 Serial 160
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Author Mancini, T.; Mari, F.; Melatti, I.; Salvo, I.; Tronci, E.; Gruber, J.; Hayes, B.; Prodanovic, M.; Elmegaard, L.
Title Parallel Statistical Model Checking for Safety Verification in Smart Grids Type Conference Article
Year 2018 Publication 2018 IEEE International Conference on Communications, Control, and Computing Technologies for Smart Grids (SmartGridComm) Abbreviated Journal
Volume Issue Pages 1-6
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Call Number (up) MCLab @ davi @ mancini-etal:2018:smartgridcomm Serial 170
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Author Mancini, T.; Mari, F.; Massini, A.; Melatti, I.; Tronci, E.
Title Anytime system level verification via parallel random exhaustive hardware in the loop simulation Type Journal Article
Year 2016 Publication Microprocessors and Microsystems Abbreviated Journal
Volume 41 Issue Pages 12-28
Keywords Model Checking of Hybrid Systems; Model checking driven simulation; Hardware in the loop simulation
Abstract Abstract System level verification of cyber-physical systems has the goal of verifying that the whole (i.e., software + hardware) system meets the given specifications. Model checkers for hybrid systems cannot handle system level verification of actual systems. Thus, Hardware In the Loop Simulation (HILS) is currently the main workhorse for system level verification. By using model checking driven exhaustive HILS, System Level Formal Verification (SLFV) can be effectively carried out for actual systems. We present a parallel random exhaustive HILS based model checker for hybrid systems that, by simulating all operational scenarios exactly once in a uniform random order, is able to provide, at any time during the verification process, an upper bound to the probability that the System Under Verification exhibits an error in a yet-to-be-simulated scenario (Omission Probability). We show effectiveness of the proposed approach by presenting experimental results on SLFV of the Inverted Pendulum on a Cart and the Fuel Control System examples in the Simulink distribution. To the best of our knowledge, no previously published model checker can exhaustively verify hybrid systems of such a size and provide at any time an upper bound to the Omission Probability.
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ISSN 0141-9331 ISBN Medium
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Call Number (up) MCLab @ davi @ Mancini201612 Serial 155
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