| |
Records |
Links |
|
Author |
Sinisi, S.; Alimguzhin, V.; Mancini, T.; Tronci, E.; Mari, F.; Leeners, B. |
|
| |
Title |
Optimal Personalised Treatment Computation through In Silico Clinical Trials on Patient Digital Twins |
Type |
Journal Article |
| |
Year |
2020 |
Publication |
|
Abbreviated Journal |
Fundamenta Informaticae |
|
| |
Volume |
174 |
Issue |
|
Pages |
283-310 |
|
| |
Keywords |
Artificial Intelligence; Virtual Physiological Human; In Silico Clinical Trials; Simulation; Personalised Medicine; In Silico Treatment Optimisation |
|
| |
Abstract |
In Silico Clinical Trials (ISCT), i.e. clinical experimental campaigns carried out by means of computer simulations, hold the promise to decrease time and cost for the safety and efficacy assessment of pharmacological treatments, reduce the need for animal and human testing, and enable precision medicine. In this paper we present methods and an algorithm that, by means of extensive computer simulation-based experimental campaigns (ISCT) guided by intelligent search, optimise a pharmacological treatment for an individual patient (precision medicine ). We show the effectiveness of our approach on a case study involving a real pharmacological treatment, namely the downregulation phase of a complex clinical protocol for assisted reproduction in humans. |
|
| |
Address |
|
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
IOS Press |
Place of Publication |
|
Editor |
|
|
| |
Language |
|
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
1875-8681 |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference  |
|
|
| |
Notes |
|
Approved |
no |
|
| |
Call Number |
MCLab @ davi @ |
Serial |
187 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Melatti, I.; Mari, F.; Mancini, T.; Prodanovic, M.; Tronci, E. |
|
| |
Title |
A Two-Layer Near-Optimal Strategy for Substation Constraint Management via Home Batteries |
Type |
Journal Article |
| |
Year |
2021 |
Publication |
IEEE Transactions on Industrial Electronics |
Abbreviated Journal |
|
|
| |
Volume |
|
Issue |
|
Pages |
1-1 |
|
| |
Keywords |
|
|
| |
Abstract |
Within electrical distribution networks, substation constraints management requires that aggregated power demand from residential users is kept within suitable bounds. Efficiency of substation constraints management can be measured as the reduction of constraints violations w.r.t. unmanaged demand. Home batteries hold the promise of enabling efficient and user-oblivious substation constraints management. Centralized control of home batteries would achieve optimal efficiency. However, it is hardly acceptable by users, since service providers (e.g., utilities or aggregators) would directly control batteries at user premises. Unfortunately, devising efficient hierarchical control strategies, thus overcoming the above problem, is far from easy. We present a novel two-layer control strategy for home batteries that avoids direct control of home devices by the service provider and at the same time yields near-optimal substation constraints management efficiency. Our simulation results on field data from 62 households in Denmark show that the substation constraints management efficiency achieved with our approach is at least 82% of the one obtained with a theoretical optimal centralized strategy. |
|
| |
Address |
|
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
|
Place of Publication |
|
Editor |
|
|
| |
Language |
|
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
|
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
To appear |
Approved |
no |
|
| |
Call Number |
MCLab @ davi @ ref9513535 |
Serial |
190 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Cavaliere, Federico; Mari, Federico; Melatti, Igor; Minei, Giovanni; Salvo, Ivano; Tronci, Enrico; Verzino, Giovanni; Yushtein, Yuri |
|
| |
Title |
Model Checking Satellite Operational Procedures |
Type |
Conference Article |
| |
Year |
2011 |
Publication |
DAta Systems In Aerospace (DASIA), Org. EuroSpace, Canadian Space Agency, CNES, ESA, EUMETSAT. San Anton, Malta, EuroSpace. |
Abbreviated Journal |
|
|
| |
Volume |
|
Issue |
|
Pages |
|
|
| |
Keywords |
|
|
| |
Abstract |
We present a model checking approach for the automatic verification of satellite operational procedures (OPs). Building a model for a complex system as a satellite is a hard task. We overcome this obstruction by using a suitable simulator (SIMSAT) for the satellite. Our approach aims at improving OP quality assurance by automatic exhaustive exploration of all possible simulation scenarios. Moreover, our solution decreases OP verification costs by using a model checker (CMurphi) to automatically drive the simulator. We model OPs as user-executed programs observing the simulator telemetries and sending telecommands to the simulator. In order to assess feasibility of our approach we present experimental results on a simple meaningful scenario. Our results show that we can save up to 90% of verification time. |
|
| |
Address |
|
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
|
Place of Publication |
|
Editor |
|
|
| |
Language |
|
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
|
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
|
Approved |
yes |
|
| |
Call Number |
Sapienza @ mari @ Dasia11 |
Serial |
13 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Mari, Federico; Melatti, Igor; Salvo, Ivano; Tronci, Enrico |
|
| |
Title |
From Boolean Relations to Control Software |
Type |
Conference Article |
| |
Year |
2011 |
Publication |
Proceedings of ICSEA 2011, The Sixth International Conference on Software Engineering Advances |
Abbreviated Journal |
|
|
| |
Volume |
|
Issue |
|
Pages |
528-533 |
|
| |
Keywords |
|
|
| |
Abstract |
Many software as well digital hardware automatic synthesis methods define the set of implementations meeting the given system specifications with a boolean relation K. In such a context a fundamental step in the software (hardware) synthesis process is finding effective solutions to the functional equation defined by K. This entails finding a (set of) boolean function(s) F (typically represented using OBDDs, Ordered Binary Decision Diagrams) such that: 1) for all x for which K is satisfiable, K(x, F(x)) = 1 holds; 2) the implementation of F is efficient with respect to given implementation parameters such as code size or execution time. While this problem has been widely studied in digital hardware synthesis, little has been done in a software synthesis context. Unfortunately the approaches developed for hardware synthesis cannot be directly used in a software context. This motivates investigation of effective methods to solve the above problem when F has to be implemented with software. In this paper we present an algorithm that, from an OBDD representation for K, generates a C code implementation for F that has the same size as the OBDD for F and a WCET (Worst Case Execution Time) linear in nr, being n = |x| the number of input arguments for functions in F and r the number of functions in F. |
|
| |
Address |
|
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
ThinkMind |
Place of Publication |
|
Editor |
|
|
| |
Language |
|
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
978-1-61208-165-6 |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
Best Paper Award |
Approved |
yes |
|
| |
Call Number |
Sapienza @ mari @ icsea11 |
Serial |
14 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Mari, Federico; Melatti, Igor; Salvo, Ivano; Tronci, Enrico |
|
| |
Title |
Synthesis of Quantized Feedback Control Software for Discrete Time Linear Hybrid Systems |
Type |
Conference Article |
| |
Year |
2010 |
Publication |
Computer Aided Verification |
Abbreviated Journal |
|
|
| |
Volume |
|
Issue |
|
Pages |
180-195 |
|
| |
Keywords |
|
|
| |
Abstract |
We present an algorithm that given a Discrete Time Linear Hybrid System returns a correct-by-construction software implementation K for a (near time optimal) robust quantized feedback controller for along with the set of states on which K is guaranteed to work correctly (controllable region). Furthermore, K has a Worst Case Execution Time linear in the number of bits of the quantization schema. |
|
| |
Address |
|
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
Springer Berlin / Heidelberg |
Place of Publication |
|
Editor |
Touili, T.; Cook, B.; Jackson, P. |
|
| |
Language |
|
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
Lecture Notes in Computer Science |
Abbreviated Series Title |
|
|
| |
Series Volume |
6174 |
Series Issue |
|
Edition |
|
|
| |
ISSN |
|
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
|
Approved |
yes |
|
| |
Call Number |
Sapienza @ mari @ cav2010 |
Serial |
16 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Mari, Federico; Melatti, Igor; Salvo, Ivano; Tronci, Enrico; Alvisi, Lorenzo; Clement, Allen; Li, Harry |
|
| |
Title |
Model Checking Coalition Nash Equilibria in MAD Distributed Systems |
Type |
Conference Article |
| |
Year |
2009 |
Publication |
Stabilization, Safety, and Security of Distributed Systems, 11th International Symposium, SSS 2009, Lyon, France, November 3-6, 2009. Proceedings |
Abbreviated Journal |
|
|
| |
Volume |
|
Issue |
|
Pages |
531-546 |
|
| |
Keywords |
|
|
| |
Abstract |
We present two OBDD based model checking algorithms for the verification of Nash equilibria in finite state mechanisms modeling Multiple Administrative Domains (MAD) distributed systems with possibly colluding agents (coalitions) and with possibly faulty or malicious nodes (Byzantine agents). Given a finite state mechanism, a proposed protocol for each agent and the maximum sizes f for Byzantine agents and q for agents collusions, our model checkers return Pass if the proposed protocol is an ε-f-q-Nash equilibrium, i.e. no coalition of size up to q may have an interest greater than ε in deviating from the proposed protocol when up to f Byzantine agents are present, Fail otherwise. We implemented our model checking algorithms within the NuSMV model checker: the first one explicitly checks equilibria for each coalition, while the second represents symbolically all coalitions. We present experimental results showing their effectiveness for moderate size mechanisms. For example, we can verify coalition Nash equilibria for mechanisms which corresponding normal form games would have more than $5 \times 10^21$ entries. Moreover, we compare the two approaches, and the explicit algorithm turns out to outperform the symbolic one. To the best of our knowledge, no model checking algorithm for verification of Nash equilibria of mechanisms with coalitions has been previously published. |
|
| |
Address |
|
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
Springer |
Place of Publication |
|
Editor |
Guerraoui, R.; Petit, F. |
|
| |
Language |
|
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
Lecture Notes in Computer Science |
Abbreviated Series Title |
|
|
| |
Series Volume |
5873 |
Series Issue |
|
Edition |
|
|
| |
ISSN |
|
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
|
Approved |
yes |
|
| |
Call Number |
Sapienza @ mari @ sss09 |
Serial |
19 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Mazzini, Silvia; Puri, Stefano; Mari, Federico; Melatti, Igor; Tronci, Enrico |
|
| |
Title |
Formal Verification at System Level |
Type |
Conference Article |
| |
Year |
2009 |
Publication |
In: DAta Systems In Aerospace (DASIA), Org. EuroSpace, Canadian Space Agency, CNES, ESA, EUMETSAT. Instanbul, Turkey, EuroSpace |
Abbreviated Journal |
|
|
| |
Volume |
|
Issue |
|
Pages |
|
|
| |
Keywords |
|
|
| |
Abstract |
System Level Analysis calls for a language comprehensible to experts with different background and yet precise enough to support meaningful analyses. SysML is emerging as an effective balance between such conflicting goals. In this paper we outline some the results obtained as for SysML based system level functional formal verification by an ESA/ESTEC study, with a collaboration among INTECS and La Sapienza University of Roma. The study focuses on SysML based system level functional requirements techniques. |
|
| |
Address |
|
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
|
Place of Publication |
|
Editor |
|
|
| |
Language |
|
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
|
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
|
Approved |
yes |
|
| |
Call Number |
Sapienza @ mari @ Dasia09 |
Serial |
20 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Della Penna, Giuseppe; Intrigila, Benedetto; Tronci, Enrico; Venturini Zilli, Marisa |
|
| |
Title |
Exploiting Transition Locality in the Disk Based Mur$\varphi$ Verifier |
Type |
Conference Article |
| |
Year |
2002 |
Publication |
4th International Conference on Formal Methods in Computer-Aided Design (FMCAD) |
Abbreviated Journal |
|
|
| |
Volume |
|
Issue |
|
Pages |
202-219 |
|
| |
Keywords |
|
|
| |
Abstract |
The main obstruction to automatic verification of Finite State Systems is the huge amount of memory required to complete the verification task (state explosion). This motivates research on distributed as well as disk based verification algorithms. In this paper we present a disk based Breadth First Explicit State Space Exploration algorithm as well as an implementation of it within the Mur$\varphi$ verifier. Our algorithm exploits transition locality (i.e. the statistical fact that most transitions lead to unvisited states or to recently visited states) to decrease disk read accesses thus reducing the time overhead due to disk usage. A disk based verification algorithm for Mur$\varphi$ has been already proposed in the literature. To measure the time speed up due to locality exploitation we compared our algorithm with such previously proposed algorithm. Our experimental results show that our disk based verification algorithm is typically more than 10 times faster than such previously proposed disk based verification algorithm. To measure the time overhead due to disk usage we compared our algorithm with RAM based verification using the (standard) Mur$\varphi$ verifier with enough memory to complete the verification task. Our experimental results show that even when using 1/10 of the RAM needed to complete verification, our disk based algorithm is only between 1.4 and 5.3 times (3 times on average) slower than (RAM) Mur$\varphi$ with enough RAM memory to complete the verification task at hand. Using our disk based Mur$\varphi$ we were able to complete verification of a protocol with about $10^9$ reachable states. This would require more than 5 gigabytes of RAM using RAM based Mur$\varphi$. |
|
| |
Address |
|
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
Springer |
Place of Publication |
Portland, OR, USA |
Editor |
Aagaard, M.; O'Leary, J.W. |
|
| |
Language |
|
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
Lecture Notes in Computer Science |
Abbreviated Series Title |
|
|
| |
Series Volume |
2517 |
Series Issue |
|
Edition |
|
|
| |
ISSN |
3-540-00116-6 |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
|
Approved |
yes |
|
| |
Call Number |
Sapienza @ mari @ fmcad02 |
Serial |
41 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Alimguzhin, V.; Mari, F.; Melatti, I.; Salvo, I.; Tronci, E. |
|
| |
Title |
Linearising Discrete Time Hybrid Systems |
Type |
Journal Article |
| |
Year |
2017 |
Publication |
IEEE Transactions on Automatic Control |
Abbreviated Journal |
|
|
| |
Volume |
62 |
Issue |
10 |
Pages |
5357-5364 |
|
| |
Keywords |
|
|
| |
Abstract |
Model Based Design approaches for embedded systems aim at generating correct-by-construction control software, guaranteeing that the closed loop system (controller and plant) meets given system level formal specifications. This technical note addresses control synthesis for safety and reachability properties of possibly non-linear discrete time hybrid systems. By means of syntactical transformations that require non-linear terms to be Lipschitz continuous functions, we over-approximate non-linear dynamics with a linear system whose controllers are guaranteed to be controllers of the original system. We evaluate performance of our approach on meaningful control synthesis benchmarks, also comparing it to a state-of-the-art tool. |
|
| |
Address |
|
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
|
Place of Publication |
|
Editor |
|
|
| |
Language |
|
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
0018-9286 |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
|
Approved |
no |
|
| |
Call Number |
Sapienza @ mari @ ref7902199 |
Serial |
164 |
|
| Permanent link to this record |
| |
|
| |
|
Author |
Della Penna, Giuseppe; Intrigila, Benedetto; Melatti, Igor; Tronci, Enrico; Venturini Zilli, Marisa |
|
| |
Title |
Finite Horizon Analysis of Markov Chains with the Mur$\varphi$ Verifier |
Type |
Conference Article |
| |
Year |
2003 |
Publication |
Correct Hardware Design and Verification Methods, 12th IFIP WG 10.5 Advanced Research Working Conference, CHARME 2003, L'Aquila, Italy, October 21-24, 2003, Proceedings |
Abbreviated Journal |
|
|
| |
Volume |
|
Issue |
|
Pages |
394-409 |
|
| |
Keywords |
|
|
| |
Abstract |
In this paper we present an explicit disk based verification algorithm for Probabilistic Systems defining discrete time/finite state Markov Chains. Given a Markov Chain and an integer k (horizon), our algorithm checks whether the probability of reaching an error state in at most k steps is below a given threshold. We present an implementation of our algorithm within a suitable extension of the Mur$\varphi$ verifier. We call the resulting probabilistic model checker FHP-Mur$\varphi$ (Finite Horizon Probabilistic Mur$\varphi$). We present experimental results comparing FHP-Mur$\varphi$ with (a finite horizon subset of) PRISM, a state-of-the-art symbolic model checker for Markov Chains. Our experimental results show that FHP-Mur$\varphi$ can handle systems that are out of reach for PRISM, namely those involving arithmetic operations on the state variables (e.g. hybrid systems). |
|
| |
Address |
|
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
Springer |
Place of Publication |
|
Editor |
Geist, D.; Tronci, E. |
|
| |
Language |
|
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
Lecture Notes in Computer Science |
Abbreviated Series Title |
|
|
| |
Series Volume |
2860 |
Series Issue |
|
Edition |
|
|
| |
ISSN |
3-540-20363-X |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
|
Approved |
yes |
|
| |
Call Number |
Sapienza @ mari @ Dimtz03 |
Serial |
84 |
|
| Permanent link to this record |
