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Mancini, T.; Mari, F.; Massini, A.; Melatti, I.; Salvo, I.; Sinisi, S.; Tronci, E.; Ehrig, R.; Röblitz, S.; Leeners, B. |
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Computing Personalised Treatments through In Silico Clinical Trials. A Case Study on Downregulation in Assisted Reproduction |
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Conference Article |
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2018 |
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25th RCRA International Workshop on “Experimental Evaluation of Algorithms for Solving Problems with Combinatorial Explosion” (RCRA 2018) |
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MCLab @ davi @ |
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175 |
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Mancini, T.; Mari, F.; Massini, A.; Melatti, I.; Tronci, E. |
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Title |
On Checking Equivalence of Simulation Scripts |
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Journal Article |
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2021 |
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Journal of Logical and Algebraic Methods in Programming |
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100640 |
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Formal verification, Simulation based formal verification, Formal Verification of cyber-physical systems, System-level formal verification |
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To support Model Based Design of Cyber-Physical Systems (CPSs) many simulation based approaches to System Level Formal Verification (SLFV) have been devised. Basically, these are Bounded Model Checking approaches (since simulation horizon is of course bounded) relying on simulators to compute the system dynamics and thereby verify the given system properties. The main obstacle to simulation based SLFV is the large number of simulation scenarios to be considered and thus the huge amount of simulation time needed to complete the verification task. To save on computation time, simulation based SLFV approaches exploit the capability of simulators to save and restore simulation states. Essentially, such a time saving is obtained by optimising the simulation script defining the simulation activity needed to carry out the verification task. Although such approaches aim to (bounded) formal verification, as a matter of fact, the proof of correctness of the methods to optimise simulation scripts basically relies on an intuitive semantics for simulation scripting languages. This hampers the possibility of formally showing that the optimisations introduced to speed up the simulation activity do not actually omit checking of relevant behaviours for the system under verification. The aim of this paper is to fill the above gap by presenting an operational semantics for simulation scripting languages and by proving soundness and completeness properties for it. This, in turn, enables formal proofs of equivalence between unoptimised and optimised simulation scripts. |
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2352-2208 |
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MCLab @ davi @ Mancini2021100640 |
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183 |
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Sinisi, S.; Alimguzhin, V.; Mancini, T.; Tronci, E.; Mari, F.; Leeners, B. |
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Title |
Optimal Personalised Treatment Computation through In Silico Clinical Trials on Patient Digital Twins |
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Journal Article |
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2020 |
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Fundamenta Informaticae |
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174 |
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283-310 |
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Artificial Intelligence; Virtual Physiological Human; In Silico Clinical Trials; Simulation; Personalised Medicine; In Silico Treatment Optimisation |
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In Silico Clinical Trials (ISCT), i.e. clinical experimental campaigns carried out by means of computer simulations, hold the promise to decrease time and cost for the safety and efficacy assessment of pharmacological treatments, reduce the need for animal and human testing, and enable precision medicine. In this paper we present methods and an algorithm that, by means of extensive computer simulation-based experimental campaigns (ISCT) guided by intelligent search, optimise a pharmacological treatment for an individual patient (precision medicine ). We show the effectiveness of our approach on a case study involving a real pharmacological treatment, namely the downregulation phase of a complex clinical protocol for assisted reproduction in humans. |
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IOS Press |
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1875-8681 |
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MCLab @ davi @ |
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187 |
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Melatti, I.; Mari, F.; Mancini, T.; Prodanovic, M.; Tronci, E. |
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Title |
A Two-Layer Near-Optimal Strategy for Substation Constraint Management via Home Batteries |
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Journal Article |
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2021 |
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IEEE Transactions on Industrial Electronics |
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1-1 |
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Within electrical distribution networks, substation constraints management requires that aggregated power demand from residential users is kept within suitable bounds. Efficiency of substation constraints management can be measured as the reduction of constraints violations w.r.t. unmanaged demand. Home batteries hold the promise of enabling efficient and user-oblivious substation constraints management. Centralized control of home batteries would achieve optimal efficiency. However, it is hardly acceptable by users, since service providers (e.g., utilities or aggregators) would directly control batteries at user premises. Unfortunately, devising efficient hierarchical control strategies, thus overcoming the above problem, is far from easy. We present a novel two-layer control strategy for home batteries that avoids direct control of home devices by the service provider and at the same time yields near-optimal substation constraints management efficiency. Our simulation results on field data from 62 households in Denmark show that the substation constraints management efficiency achieved with our approach is at least 82% of the one obtained with a theoretical optimal centralized strategy. |
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To appear |
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MCLab @ davi @ ref9513535 |
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190 |
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Author |
Mazzini, Silvia; Puri, Stefano; Mari, Federico; Melatti, Igor; Tronci, Enrico |
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Title |
Formal Verification at System Level |
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Conference Article |
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2009 |
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In: DAta Systems In Aerospace (DASIA), Org. EuroSpace, Canadian Space Agency, CNES, ESA, EUMETSAT. Instanbul, Turkey, EuroSpace |
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System Level Analysis calls for a language comprehensible to experts with different background and yet precise enough to support meaningful analyses. SysML is emerging as an effective balance between such conflicting goals. In this paper we outline some the results obtained as for SysML based system level functional formal verification by an ESA/ESTEC study, with a collaboration among INTECS and La Sapienza University of Roma. The study focuses on SysML based system level functional requirements techniques. |
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yes |
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Sapienza @ mari @ Dasia09 |
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20 |
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Alimguzhin, V.; Mari, F.; Melatti, I.; Salvo, I.; Tronci, E. |
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Title |
Linearising Discrete Time Hybrid Systems |
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2017 |
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IEEE Transactions on Automatic Control |
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62 |
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10 |
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5357-5364 |
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Model Based Design approaches for embedded systems aim at generating correct-by-construction control software, guaranteeing that the closed loop system (controller and plant) meets given system level formal specifications. This technical note addresses control synthesis for safety and reachability properties of possibly non-linear discrete time hybrid systems. By means of syntactical transformations that require non-linear terms to be Lipschitz continuous functions, we over-approximate non-linear dynamics with a linear system whose controllers are guaranteed to be controllers of the original system. We evaluate performance of our approach on meaningful control synthesis benchmarks, also comparing it to a state-of-the-art tool. |
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0018-9286 |
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Sapienza @ mari @ ref7902199 |
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164 |
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Mari, Federico; Melatti, Igor; Salvo, Ivano; Tronci, Enrico |
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Title |
Quantized Feedback Control Software Synthesis from System Level Formal Specifications for Buck DC/DC Converters |
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Report |
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2011 |
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abs/1105.5640 |
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Many Embedded Systems are indeed Software Based Control Systems (SBCSs), that is control systems whose controller consists of control software running on a microcontroller device. This motivates investigation on Formal Model Based Design approaches for automatic synthesis of SBCS control software. In previous works we presented an algorithm, along with a tool QKS implementing it, that from a formal model (as a Discrete Time Linear Hybrid System, DTLHS) of the controlled system (plant), implementation specifications (that is, number of bits in the Analog-to-Digital, AD, conversion) and System Level Formal Specifications (that is, safety and liveness requirements for the closed loop system) returns correct-by-construction control software that has a Worst Case Execution Time (WCET) linear in the number of AD bits and meets the given specifications. In this technical report we present full experimental results on using it to synthesize control software for two versions of buck DC-DC converters (single-input and multi-input), a widely used mixed-mode analog circuit. |
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CoRR, Technical Report |
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yes |
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Sapienza @ mari @ |
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106 |
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Alimguzhin, Vadim; Mari, Federico; Melatti, Igor; Salvo, Ivano; Tronci, Enrico |
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Title |
Automatic Control Software Synthesis for Quantized Discrete Time Hybrid Systems |
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2012 |
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Proceedings of the 51th IEEE Conference on Decision and Control, CDC 2012, December 10-13, 2012, Maui, HI, USA |
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6120-6125 |
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IEEE |
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978-1-4673-2065-8 |
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Techreport version can be found at http://arxiv.org/abs/1207.4098 |
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yes |
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Sapienza @ mari @ cdc12 |
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96 |
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Mari, Federico; Melatti, Igor; Salvo, Ivano; Tronci, Enrico |
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Title |
Linear Constraints as a Modeling Language for Discrete Time Hybrid Systems |
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2012 |
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Proceedings of ICSEA 2012, The Seventh International Conference on Software Engineering Advances |
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664-671 |
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ThinkMind |
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Sapienza @ mari @ icsea12 |
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98 |
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Mari, Federico; Melatti, Igor; Salvo, Ivano; Tronci, Enrico |
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Title |
Control Software Visualization |
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2012 |
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Proceedings of INFOCOMP 2012, The Second International Conference on Advanced Communications and Computation |
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15-20 |
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ThinkMind |
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978-1-61208-226-4 |
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Sapienza @ mari @ infocomp2012 |
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100 |
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