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	Author	Sinisi, S.; Alimguzhin, V.; Mancini, T.; Tronci, E.; Mari, F.; Leeners, B.
	Title	Optimal Personalised Treatment Computation through In Silico Clinical Trials on Patient Digital Twins			Type	Journal Article
	Year	2020	Publication		Abbreviated Journal	Fundamenta Informaticae
	Volume	174	Issue		Pages	283-310
	Keywords	Artificial Intelligence; Virtual Physiological Human; In Silico Clinical Trials; Simulation; Personalised Medicine; In Silico Treatment Optimisation
	Abstract	In Silico Clinical Trials (ISCT), i.e. clinical experimental campaigns carried out by means of computer simulations, hold the promise to decrease time and cost for the safety and efficacy assessment of pharmacological treatments, reduce the need for animal and human testing, and enable precision medicine. In this paper we present methods and an algorithm that, by means of extensive computer simulation-based experimental campaigns (ISCT) guided by intelligent search, optimise a pharmacological treatment for an individual patient (precision medicine ). We show the effectiveness of our approach on a case study involving a real pharmacological treatment, namely the downregulation phase of a complex clinical protocol for assisted reproduction in humans.
	Address
	Corporate Author				Thesis
	Publisher	IOS Press	Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN	1875-8681	ISBN		Medium
	Area		Expedition		Conference
	Notes				Approved	no
	Call Number	MCLab @ davi @			Serial	187
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	Author	Melatti, I.; Mari, F.; Mancini, T.; Prodanovic, M.; Tronci, E.
	Title	A Two-Layer Near-Optimal Strategy for Substation Constraint Management via Home Batteries			Type	Journal Article
	Year	2021	Publication	IEEE Transactions on Industrial Electronics	Abbreviated Journal
	Volume		Issue		Pages	1-1
	Keywords
	Abstract	Within electrical distribution networks, substation constraints management requires that aggregated power demand from residential users is kept within suitable bounds. Efficiency of substation constraints management can be measured as the reduction of constraints violations w.r.t. unmanaged demand. Home batteries hold the promise of enabling efficient and user-oblivious substation constraints management. Centralized control of home batteries would achieve optimal efficiency. However, it is hardly acceptable by users, since service providers (e.g., utilities or aggregators) would directly control batteries at user premises. Unfortunately, devising efficient hierarchical control strategies, thus overcoming the above problem, is far from easy. We present a novel two-layer control strategy for home batteries that avoids direct control of home devices by the service provider and at the same time yields near-optimal substation constraints management efficiency. Our simulation results on field data from 62 households in Denmark show that the substation constraints management efficiency achieved with our approach is at least 82% of the one obtained with a theoretical optimal centralized strategy.
	Address
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN		ISBN		Medium
	Area		Expedition		Conference
	Notes	To appear			Approved	no
	Call Number	MCLab @ davi @ ref9513535			Serial	190
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	Author	Della Penna, Giuseppe; Intrigila, Benedetto; Melatti, Igor; Tronci, Enrico; Venturini Zilli, Marisa
	Title	Integrating RAM and Disk Based Verification within the Mur$\varphi$ Verifier			Type	Conference Article
	Year	2003	Publication	Correct Hardware Design and Verification Methods, 12th IFIP WG 10.5 Advanced Research Working Conference, CHARME 2003, L'Aquila, Italy, October 21-24, 2003, Proceedings	Abbreviated Journal
	Volume		Issue		Pages	277-282
	Keywords
	Abstract	We present a verification algorithm that can automatically switch from RAM based verification to disk based verification without discarding the work done during the RAM based verification phase. This avoids having to choose beforehand the proper verification algorithm. Our experimental results show that typically our integrated algorithm is as fast as (sometime faster than) the fastest of the two base (i.e. RAM based and disk based) verification algorithms.
	Address
	Corporate Author				Thesis
	Publisher	Springer	Place of Publication		Editor	Geist, D.; Tronci, E.
	Language		Summary Language		Original Title
	Series Editor		Series Title	Lecture Notes in Computer Science	Abbreviated Series Title
	Series Volume	2860	Series Issue		Edition
	ISSN	3-540-20363-X	ISBN		Medium
	Area		Expedition		Conference
	Notes				Approved	yes
	Call Number	Sapienza @ mari @ DIMTZ03a			Serial	85
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	Author	Mari, Federico; Melatti, Igor; Salvo, Ivano; Tronci, Enrico
	Title	From Boolean Relations to Control Software			Type	Conference Article
	Year	2011	Publication	Proceedings of ICSEA 2011, The Sixth International Conference on Software Engineering Advances	Abbreviated Journal
	Volume		Issue		Pages	528-533
	Keywords
	Abstract	Many software as well digital hardware automatic synthesis methods define the set of implementations meeting the given system specifications with a boolean relation K. In such a context a fundamental step in the software (hardware) synthesis process is finding effective solutions to the functional equation defined by K. This entails finding a (set of) boolean function(s) F (typically represented using OBDDs, Ordered Binary Decision Diagrams) such that: 1) for all x for which K is satisfiable, K(x, F(x)) = 1 holds; 2) the implementation of F is efficient with respect to given implementation parameters such as code size or execution time. While this problem has been widely studied in digital hardware synthesis, little has been done in a software synthesis context. Unfortunately the approaches developed for hardware synthesis cannot be directly used in a software context. This motivates investigation of effective methods to solve the above problem when F has to be implemented with software. In this paper we present an algorithm that, from an OBDD representation for K, generates a C code implementation for F that has the same size as the OBDD for F and a WCET (Worst Case Execution Time) linear in nr, being n = \|x\| the number of input arguments for functions in F and r the number of functions in F.
	Address
	Corporate Author				Thesis
	Publisher	ThinkMind	Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN	978-1-61208-165-6	ISBN		Medium
	Area		Expedition		Conference
	Notes	Best Paper Award			Approved	yes
	Call Number	Sapienza @ mari @ icsea11			Serial	14
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	Author	Mari, Federico; Melatti, Igor; Salvo, Ivano; Tronci, Enrico
	Title	Synthesis of Quantized Feedback Control Software for Discrete Time Linear Hybrid Systems			Type	Conference Article
	Year	2010	Publication	Computer Aided Verification	Abbreviated Journal
	Volume		Issue		Pages	180-195
	Keywords
	Abstract	We present an algorithm that given a Discrete Time Linear Hybrid System returns a correct-by-construction software implementation K for a (near time optimal) robust quantized feedback controller for along with the set of states on which K is guaranteed to work correctly (controllable region). Furthermore, K has a Worst Case Execution Time linear in the number of bits of the quantization schema.
	Address
	Corporate Author				Thesis
	Publisher	Springer Berlin / Heidelberg	Place of Publication		Editor	Touili, T.; Cook, B.; Jackson, P.
	Language		Summary Language		Original Title
	Series Editor		Series Title	Lecture Notes in Computer Science	Abbreviated Series Title
	Series Volume	6174	Series Issue		Edition
	ISSN		ISBN		Medium
	Area		Expedition		Conference
	Notes				Approved	yes
	Call Number	Sapienza @ mari @ cav2010			Serial	16
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	Author	Bobbio, Andrea; Ciancamerla, Ester; Di Blasi, Saverio; Iacomini, Alessandro; Mari, Federico; Melatti, Igor; Minichino, Michele; Scarlatti, Alessandro; Tronci, Enrico; Terruggia, Roberta; Zendri, Emilio
	Title	Risk analysis via heterogeneous models of SCADA interconnecting Power Grids and Telco networks			Type	Conference Article
	Year	2009	Publication	Proceedings of Fourth International Conference on Risks and Security of Internet and Systems (CRiSIS)	Abbreviated Journal
	Volume		Issue		Pages	90-97
	Keywords
	Abstract	The automation of power grids by means of supervisory control and data acquisition (SCADA) systems has led to an improvement of power grid operations and functionalities but also to pervasive cyber interdependencies between power grids and telecommunication networks. Many power grid services are increasingly depending upon the adequate functionality of SCADA system which in turn strictly depends on the adequate functionality of its communication infrastructure. We propose to tackle the SCADA risk analysis by means of different and heterogeneous modeling techniques and software tools. We demonstrate the applicability of our approach through a case study on an actual SCADA system for an electrical power distribution grid. The modeling techniques we discuss aim at providing a probabilistic dependability analysis, followed by a worst case analysis in presence of malicious attacks and a real-time performance evaluation.
	Address
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN		ISBN		Medium
	Area		Expedition		Conference	Fourth International Conference on Risks and Security of Internet and Systems (CRiSIS)
	Notes				Approved	yes
	Call Number	Sapienza @ mari @ crisis09			Serial	17
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	Author	Mari, Federico; Melatti, Igor; Salvo, Ivano; Tronci, Enrico; Alvisi, Lorenzo; Clement, Allen; Li, Harry
	Title	Model Checking Coalition Nash Equilibria in MAD Distributed Systems			Type	Conference Article
	Year	2009	Publication	Stabilization, Safety, and Security of Distributed Systems, 11th International Symposium, SSS 2009, Lyon, France, November 3-6, 2009. Proceedings	Abbreviated Journal
	Volume		Issue		Pages	531-546
	Keywords
	Abstract	We present two OBDD based model checking algorithms for the verification of Nash equilibria in finite state mechanisms modeling Multiple Administrative Domains (MAD) distributed systems with possibly colluding agents (coalitions) and with possibly faulty or malicious nodes (Byzantine agents). Given a finite state mechanism, a proposed protocol for each agent and the maximum sizes f for Byzantine agents and q for agents collusions, our model checkers return Pass if the proposed protocol is an ε-f-q-Nash equilibrium, i.e. no coalition of size up to q may have an interest greater than ε in deviating from the proposed protocol when up to f Byzantine agents are present, Fail otherwise. We implemented our model checking algorithms within the NuSMV model checker: the first one explicitly checks equilibria for each coalition, while the second represents symbolically all coalitions. We present experimental results showing their effectiveness for moderate size mechanisms. For example, we can verify coalition Nash equilibria for mechanisms which corresponding normal form games would have more than $5 \times 10^21$ entries. Moreover, we compare the two approaches, and the explicit algorithm turns out to outperform the symbolic one. To the best of our knowledge, no model checking algorithm for verification of Nash equilibria of mechanisms with coalitions has been previously published.
	Address
	Corporate Author				Thesis
	Publisher	Springer	Place of Publication		Editor	Guerraoui, R.; Petit, F.
	Language		Summary Language		Original Title
	Series Editor		Series Title	Lecture Notes in Computer Science	Abbreviated Series Title
	Series Volume	5873	Series Issue		Edition
	ISSN		ISBN		Medium
	Area		Expedition		Conference
	Notes				Approved	yes
	Call Number	Sapienza @ mari @ sss09			Serial	19
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	Author	Mazzini, Silvia; Puri, Stefano; Mari, Federico; Melatti, Igor; Tronci, Enrico
	Title	Formal Verification at System Level			Type	Conference Article
	Year	2009	Publication	In: DAta Systems In Aerospace (DASIA), Org. EuroSpace, Canadian Space Agency, CNES, ESA, EUMETSAT. Instanbul, Turkey, EuroSpace	Abbreviated Journal
	Volume		Issue		Pages
	Keywords
	Abstract	System Level Analysis calls for a language comprehensible to experts with different background and yet precise enough to support meaningful analyses. SysML is emerging as an effective balance between such conflicting goals. In this paper we outline some the results obtained as for SysML based system level functional formal verification by an ESA/ESTEC study, with a collaboration among INTECS and La Sapienza University of Roma. The study focuses on SysML based system level functional requirements techniques.
	Address
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN		ISBN		Medium
	Area		Expedition		Conference
	Notes				Approved	yes
	Call Number	Sapienza @ mari @ Dasia09			Serial	20
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	Author	Della Penna, Giuseppe; Intrigila, Benedetto; Tronci, Enrico; Venturini Zilli, Marisa
	Title	Synchronized regular expressions			Type	Journal Article
	Year	2003	Publication	Acta Inf.	Abbreviated Journal
	Volume	39	Issue	1	Pages	31-70
	Keywords
	Abstract	Text manipulation is one of the most common tasks for everyone using a computer. The increasing number of textual information in electronic format that every computer user collects everyday also increases the need of more powerful tools to interact with texts. Indeed, much work has been done to provide simple and versatile tools that can be useful for the most common text manipulation tasks. Regular Expressions (RE), introduced by Kleene, are well known in the formal language theory. RE have been extended in various ways, depending on the application of interest. In almost all the implementations of RE search algorithms (e.g. the egrep [15] UNIX command, or the Perl [20] language pattern matching constructs) we find backreferences, i.e. expressions that make reference to the string matched by a previous subexpression. Generally speaking, it seems that all kinds of synchronizations between subexpressions in a RE can be very useful when interacting with texts. In this paper we introduce the Synchronized Regular Expressions (SRE) as an extension of the Regular Expressions. We use SRE to present a formal study of the already known backreferences extension, and of a new extension proposed by us, which we call the synchronized exponents. Moreover, since we are dealing with formalisms that should have a practical utility and be used in real applications, we have the problem of how to present SRE to the final users. Therefore, in this paper we also propose a user-friendly syntax for SRE to be used in implementations of SRE-powered search algorithms.
	Address
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN		ISBN		Medium
	Area		Expedition		Conference
	Notes				Approved	yes
	Call Number	Sapienza @ mari @ actainf03			Serial	39
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	Author	Della Penna, Giuseppe; Intrigila, Benedetto; Tronci, Enrico; Venturini Zilli, Marisa
	Title	Exploiting Transition Locality in the Disk Based Mur$\varphi$ Verifier			Type	Conference Article
	Year	2002	Publication	4th International Conference on Formal Methods in Computer-Aided Design (FMCAD)	Abbreviated Journal
	Volume		Issue		Pages	202-219
	Keywords
	Abstract	The main obstruction to automatic verification of Finite State Systems is the huge amount of memory required to complete the verification task (state explosion). This motivates research on distributed as well as disk based verification algorithms. In this paper we present a disk based Breadth First Explicit State Space Exploration algorithm as well as an implementation of it within the Mur$\varphi$ verifier. Our algorithm exploits transition locality (i.e. the statistical fact that most transitions lead to unvisited states or to recently visited states) to decrease disk read accesses thus reducing the time overhead due to disk usage. A disk based verification algorithm for Mur$\varphi$ has been already proposed in the literature. To measure the time speed up due to locality exploitation we compared our algorithm with such previously proposed algorithm. Our experimental results show that our disk based verification algorithm is typically more than 10 times faster than such previously proposed disk based verification algorithm. To measure the time overhead due to disk usage we compared our algorithm with RAM based verification using the (standard) Mur$\varphi$ verifier with enough memory to complete the verification task. Our experimental results show that even when using 1/10 of the RAM needed to complete verification, our disk based algorithm is only between 1.4 and 5.3 times (3 times on average) slower than (RAM) Mur$\varphi$ with enough RAM memory to complete the verification task at hand. Using our disk based Mur$\varphi$ we were able to complete verification of a protocol with about $10^9$ reachable states. This would require more than 5 gigabytes of RAM using RAM based Mur$\varphi$.
	Address
	Corporate Author				Thesis
	Publisher	Springer	Place of Publication	Portland, OR, USA	Editor	Aagaard, M.; O'Leary, J.W.
	Language		Summary Language		Original Title
	Series Editor		Series Title	Lecture Notes in Computer Science	Abbreviated Series Title
	Series Volume	2517	Series Issue		Edition
	ISSN	3-540-00116-6	ISBN		Medium
	Area		Expedition		Conference
	Notes				Approved	yes
	Call Number	Sapienza @ mari @ fmcad02			Serial	41
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