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Author |
Sinisi, S.; Alimguzhin, V.; Mancini, T.; Tronci, E.; Mari, F.; Leeners, B. |
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Title |
Optimal Personalised Treatment Computation through In Silico Clinical Trials on Patient Digital Twins |
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Journal Article |
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Year |
2020 |
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Abbreviated Journal |
Fundamenta Informaticae |
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Volume |
174 |
Issue |
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Pages  |
283-310 |
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Keywords |
Artificial Intelligence; Virtual Physiological Human; In Silico Clinical Trials; Simulation; Personalised Medicine; In Silico Treatment Optimisation |
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Abstract |
In Silico Clinical Trials (ISCT), i.e. clinical experimental campaigns carried out by means of computer simulations, hold the promise to decrease time and cost for the safety and efficacy assessment of pharmacological treatments, reduce the need for animal and human testing, and enable precision medicine. In this paper we present methods and an algorithm that, by means of extensive computer simulation-based experimental campaigns (ISCT) guided by intelligent search, optimise a pharmacological treatment for an individual patient (precision medicine ). We show the effectiveness of our approach on a case study involving a real pharmacological treatment, namely the downregulation phase of a complex clinical protocol for assisted reproduction in humans. |
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IOS Press |
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1875-8681 |
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Call Number |
MCLab @ davi @ |
Serial |
187 |
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Author |
Della Penna, Giuseppe; Tofani, Alberto; Pecorari, Marcello; Raparelli, Orazio; Intrigila, Benedetto; Melatti, Igor; Tronci, Enrico |
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Title |
A Case Study on Automated Generation of Integration Tests |
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Conference Article |
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Year |
2006 |
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Fdl |
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Pages |
278-284 |
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Ecsi |
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978-3-00-019710-9 |
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yes |
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Call Number |
Sapienza @ mari @ Dtprimt06 |
Serial |
27 |
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Author |
Della Penna, Giuseppe; Intrigila, Benedetto; Melatti, Igor; Tronci, Enrico; Venturini Zilli, Marisa |
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Title |
Integrating RAM and Disk Based Verification within the Mur$\varphi$ Verifier |
Type |
Conference Article |
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Year |
2003 |
Publication |
Correct Hardware Design and Verification Methods, 12th IFIP WG 10.5 Advanced Research Working Conference, CHARME 2003, L'Aquila, Italy, October 21-24, 2003, Proceedings |
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Pages |
277-282 |
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Abstract |
We present a verification algorithm that can automatically switch from RAM based verification to disk based verification without discarding the work done during the RAM based verification phase. This avoids having to choose beforehand the proper verification algorithm. Our experimental results show that typically our integrated algorithm is as fast as (sometime faster than) the fastest of the two base (i.e. RAM based and disk based) verification algorithms. |
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Springer |
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Geist, D.; Tronci, E. |
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Series Title |
Lecture Notes in Computer Science |
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Series Volume |
2860 |
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3-540-20363-X |
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yes |
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Call Number |
Sapienza @ mari @ DIMTZ03a |
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85 |
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Author |
Gribaudo, Marco; Horváth, Andras; Bobbio, Andrea; Tronci, Enrico; Ciancamerla, Ester; Minichino, Michele |
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Title |
Model-Checking Based on Fluid Petri Nets for the Temperature Control System of the ICARO Co-generative Plant |
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Conference Article |
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Year |
2002 |
Publication |
21st International Conference on Computer Safety, Reliability and Security (SAFECOMP) |
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273-283 |
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The modeling and analysis of hybrid systems is a recent and challenging research area which is actually dominated by two main lines: a functional analysis based on the description of the system in terms of discrete state (hybrid) automata (whose goal is to ascertain for conformity and reachability properties), and a stochastic analysis (whose aim is to provide performance and dependability measures). This paper investigates a unifying view between formal methods and stochastic methods by proposing an analysis methodology of hybrid systems based on Fluid Petri Nets (FPN). It is shown that the same FPN model can be fed to a functional analyser for model checking as well as to a stochastic analyser for performance evaluation. We illustrate our approach and show its usefulness by applying it to a “real world†hybrid system: the temperature control system of a co-generative plant. |
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Springer |
Place of Publication |
Catania, Italy |
Editor |
Anderson, S.; Bologna, S.; Felici, M. |
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Lecture Notes in Computer Science |
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Series Volume |
2434 |
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3-540-44157-3 |
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yes |
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Call Number |
Sapienza @ mari @ safecomp02 |
Serial |
42 |
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Author |
Mari, Federico; Melatti, Igor; Tronci, Enrico; Finzi, Alberto |
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Title |
A multi-hop advertising discovery and delivering protocol for multi administrative domain MANET |
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Journal Article |
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Year |
2013 |
Publication |
Mobile Information Systems |
Abbreviated Journal |
Mobile Information Systems |
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Volume |
3 |
Issue |
9 |
Pages |
261-280 |
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IOS Press |
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1574-017x (Print) 1875-905X (Online) |
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no |
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Call Number |
Sapienza @ melatti @ |
Serial |
109 |
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Author |
Tronci, Enrico; Della Penna, Giuseppe; Intrigila, Benedetto; Venturini Zilli, Marisa |
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Title |
Exploiting Transition Locality in Automatic Verification |
Type |
Conference Article |
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Year |
2001 |
Publication |
11th IFIP WG 10.5 Advanced Research Working Conference on Correct Hardware Design and Verification Methods (CHARME) |
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Pages |
259-274 |
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Abstract |
In this paper we present an algorithm to contrast state explosion when using Explicit State Space Exploration to verify protocols. We show experimentally that protocols exhibit transition locality. We present a verification algorithm that exploits transition locality as well as an implementation of it within the Mur$\varphi$ verifier. Our algorithm is compatible with all Breadth First (BF) optimization techniques present in the Mur$\varphi$ verifier and it is by no means a substitute for any of them. In fact, since our algorithm trades space with time, it is typically most useful when one runs out of memory and has already used all other state reduction techniques present in the Mur$\varphi$ verifier. Our experimental results show that using our approach we can typically save more than 40% of RAM with an average time penalty of about 50% when using (Mur$\varphi$) bit compression and 100% when using bit compression and hash compaction. |
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Springer |
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Livingston, Scotland, UK |
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Margaria, T.; Melham, T.F. |
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Lecture Notes in Computer Science |
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Series Volume |
2144 |
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ISSN |
3-540-42541-1 |
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yes |
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Call Number |
Sapienza @ mari @ charme01 |
Serial |
44 |
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Author |
Lanotte, Ruggero; Maggiolo-Schettini, Andrea; Tini, Simone; Troina, Angelo; Tronci, Enrico |
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Title |
Automatic Covert Channel Analysis of a Multilevel Secure Component |
Type |
Conference Article |
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Year |
2004 |
Publication |
Information and Communications Security, 6th International Conference, ICICS 2004, Malaga, Spain, October 27-29, 2004, Proceedings |
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249-261 |
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The NRL Pump protocol defines a multilevel secure component whose goal is to minimize leaks of information from high level systems to lower level systems, without degrading average time performances. We define a probabilistic model for the NRL Pump and show how a probabilistic model checker (FHP-mur$\varphi$) can be used to estimate the capacity of a probabilistic covert channel in the NRL Pump. We are able to compute the probability of a security violation as a function of time for various configurations of the system parameters (e.g. buffer sizes, moving average size, etc). Because of the model complexity, our results cannot be obtained using an analytical approach and, because of the low probabilities involved, it can be hard to obtain them using a simulator. |
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Springer |
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Lopez, J.; Qing, S.; Okamoto, E. |
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Lecture Notes in Computer Science |
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Series Volume |
3269 |
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yes |
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Call Number |
Sapienza @ mari @ icics04 |
Serial |
34 |
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Author |
Tronci, Enrico |
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Title |
Automatic Synthesis of Control Software for an Industrial Automation Control System |
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Conference Article |
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Year |
1999 |
Publication |
Proc.of: 14th IEEE International Conference on: Automated Software Engineering (ASE) |
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247-250 |
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We present a case study on automatic synthesis of control software from formal specifications for an industrial automation control system. Our aim is to compare the effectiveness (i.e. design effort and controller quality) of automatic controller synthesis from closed loop formal specifications with that of manual controller design, followed by automatic verification. Our experimental results show that for industrial automation control systems, automatic synthesis is a viable and profitable (especially as far as design effort is concerned) alternative to manual design, followed by automatic verification. |
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Cocoa Beach, Florida, USA |
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yes |
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Call Number |
Sapienza @ mari @ ase99 |
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49 |
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Author |
Lanotte, Ruggero; Maggiolo-Schettini, Andrea; Tini, Simone; Troina, Angelo; Tronci, Enrico |
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Title |
Automatic Analysis of the NRL Pump |
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Journal Article |
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Year |
2004 |
Publication |
Electr. Notes Theor. Comput. Sci. |
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Volume |
99 |
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Pages |
245-266 |
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Abstract |
We define a probabilistic model for the NRL Pump and using FHP-mur$\varphi$ show experimentally that there exists a probabilistic covert channel whose capacity depends on various NRL Pump parameters (e.g. buffer size, number of samples in the moving average, etc). |
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yes |
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Call Number |
Sapienza @ mari @ entcs04 |
Serial |
36 |
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Author |
Mari, Federico; Melatti, Igor; Salvo, Ivano; Tronci, Enrico |
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Title |
Undecidability of Quantized State Feedback Control for Discrete Time Linear Hybrid Systems |
Type |
Book Chapter |
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Year |
2012 |
Publication |
Theoretical Aspects of Computing – ICTAC 2012 |
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243-258 |
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Springer Berlin Heidelberg |
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Roychoudhury, A.; D'Souza, M. |
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Lecture Notes in Computer Science |
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Series Volume |
7521 |
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978-3-642-32942-5 |
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yes |
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Call Number |
Sapienza @ mari @ Mari2012 |
Serial |
99 |
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