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Fischer, S.; Ehrig, R.; Schaefer, S.; Tronci, E.; Mancini, T.; Egli, M.; Ille, F.; Krueger, T.H.C.; Leeners, B.; Roeblitz, S. |
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Title |
Mathematical Modeling and Simulation Provides Evidence for New Strategies of Ovarian Stimulation |
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Journal Article |
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2021 |
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Frontiers in Endocrinology |
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12 |
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117 |
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New approaches to ovarian stimulation protocols, such as luteal start, random start or double stimulation, allow for flexibility in ovarian stimulation at different phases of the menstrual cycle. It has been proposed that the success of these methods is based on the continuous growth of multiple cohorts (“waves”) of follicles throughout the menstrual cycle which leads to the availability of ovarian follicles for ovarian controlled stimulation at several time points. Though several preliminary studies have been published, their scientific evidence has not been considered as being strong enough to integrate these results into routine clinical practice. This work aims at adding further scientific evidence about the efficiency of variable-start protocols and underpinning the theory of follicular waves by using mathematical modeling and numerical simulations. For this purpose, we have modified and coupled two previously published models, one describing the time course of hormones and one describing competitive follicular growth in a normal menstrual cycle. The coupled model is used to test ovarian stimulation protocols in silico. Simulation results show the occurrence of follicles in a wave-like manner during a normal menstrual cycle and qualitatively predict the outcome of ovarian stimulation initiated at different time points of the menstrual cycle. |
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1664-2392 |
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MCLab @ davi @ ref10.3389/fendo.2021.613048 |
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189 |
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Fantechi, Alessandro; Gnesi, Stefania; Mazzanti, Franco; Pugliese, Rosario; Tronci, Enrico |
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Title |
A Symbolic Model Checker for ACTL |
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1998 |
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International Workshop on Current Trends in Applied Formal Method (FM-Trends) |
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228-242 |
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We present SAM, a symbolic model checker for ACTL, the action-based version of CTL. SAM relies on implicit representations of Labeled Transition Systems (LTSs), the semantic domain for ACTL formulae, and uses symbolic manipulation algorithms. SAM has been realized by translating (networks of) LTSs and, possibly recursive, ACTL formulae into BSP (Boolean Symbolic Programming), a programming language aiming at defining computations on boolean functions, and by using the BSP interpreter to carry out computations (i.e. verifications). |
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Springer |
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Boppard, Germany |
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Hutter, D.; Stephan, W.; Traverso, P.; Ullmann, M. |
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Lecture Notes in Computer Science |
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1641 |
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3-540-66462-9 |
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yes |
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Sapienza @ mari @ fm-trends98 |
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51 |
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Ehrig, R.; Dierkes, T.; Schaefer, S.; Roeblitz, S.; Tronci, E.; Mancini, T.; Salvo, I.; Alimguzhin, V.; Mari, F.; Melatti, I.; Massini, A.; Leeners, B.; Krueger, T.H.C.; Egli, M.; Ille, F. |
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An integrative approach for model driven computation of treatments in reproductive medicine |
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2015 |
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Proceedings of the 15th International Symposium on Mathematical and Computational Biology (BIOMAT 2015), Rorkee, India |
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Sapienza @ preissler @ Ehrig_etal2015 |
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144 |
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Driouich, Y.; Parente, M.; Tronci, E. |
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Model Checking Cyber-Physical Energy Systems |
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Conference Article |
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2018 |
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Proceedings of 2017 International Renewable and Sustainable Energy Conference, IRSEC 2017 |
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Institute of Electrical and Electronics Engineers Inc. |
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MCLab @ davi @ Driouich2018 |
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177 |
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Driouich, Y.; Parente, M.; Tronci, E. |
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A methodology for a complete simulation of Cyber-Physical Energy Systems |
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Conference Article |
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2018 |
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EESMS 2018 – Environmental, Energy, and Structural Monitoring Systems, Proceedings |
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1-5 |
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no |
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MCLab @ davi @ Driouich20181 |
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169 |
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Author |
Driouich, Y.; Parente, M.; Tronci, E. |
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Title |
Modeling cyber-physical systems for automatic verification |
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Conference Article |
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2017 |
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14th International Conference on Synthesis, Modeling, Analysis and Simulation Methods and Applications to Circuit Design (SMACD 2017) |
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1-4 |
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cyber-physical systems;formal verification;maximum power point trackers;power engineering computing;Modelica;automatic verification;complex power electronics systems;cyber-physical systems modeling;distributed maximum power point tracking system;open standard modeling language;Computational modeling;Control systems;Integrated circuit modeling;Mathematical model;Maximum power point trackers;Object oriented modeling;Radiation effects;Automatic Formal Verification;Cyber-Physical Systems;DMPPT;Modeling;Photovoltaic systems;Simulation;System Analysis and Design |
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MCLab @ davi @ ref7981621 |
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168 |
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Dipoppa, G.; D'Alessandro, G.; Semprini, R.; Tronci, E. |
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Integrating Automatic Verification of Safety Requirements in Railway Interlocking System Design |
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Conference Article |
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2001 |
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High Assurance Systems Engineering, 2001. Sixth IEEE International Symposium on |
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209-219 |
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A railway interlocking system (RIS) is an embedded system (namely a supervisory control system) that ensures the safe, operation of the devices in a railway station. RIS is a safety critical system. We explore the possibility of integrating automatic formal verification methods in a given industry RIS design flow. The main obstructions to be overcome in our work are: selecting a formal verification tool that is efficient enough to solve the verification problems at hand; and devising a cost effective integration strategy for such tool. We were able to devise a successful integration strategy meeting the above constraints without requiring major modification in the pre-existent design flow nor retraining of personnel. We run verification experiments for a RIS designed for the Singapore Subway. The experiments show that the RIS design flow obtained from our integration strategy is able to automatically verify real life RIS designs. |
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IEEE Computer Society |
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Albuquerque, NM, USA |
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0-7695-1275-5 |
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yes |
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Sapienza @ mari @ hase01 |
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45 |
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Della Penna, Giuseppe; Tofani, Alberto; Pecorari, Marcello; Raparelli, Orazio; Intrigila, Benedetto; Melatti, Igor; Tronci, Enrico |
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A Case Study on Automated Generation of Integration Tests |
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2006 |
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Fdl |
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278-284 |
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Ecsi |
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978-3-00-019710-9 |
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yes |
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Sapienza @ mari @ Dtprimt06 |
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27 |
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Della Penna, Giuseppe; Magazzeni, Daniele; Tofani, Alberto; Intrigila, Benedetto; Melatti, Igor; Tronci, Enrico |
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Automated Generation Of Optimal Controllers Through Model Checking Techniques |
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2008 |
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Informatics in Control Automation and Robotics. Selected Papers from ICINCO 2006 |
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107-119 |
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Springer |
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yes |
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Sapienza @ mari @ Dmtmt08 |
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26 |
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Della Penna, Giuseppe; Magazzeni, Daniele; Tofani, Alberto; Intrigila, Benedetto; Melatti, Igor; Tronci, Enrico |
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Title |
Automated Generation of Optimal Controllers through Model Checking Techniques |
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Conference Article |
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2006 |
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Icinco-Icso |
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26-33 |
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We present a methodology for the synthesis of controllers, which exploits (explicit) model checking techniques. That is, we can cope with the systematic exploration of a very large state space. This methodology can be applied to systems where other approaches fail. In particular, we can consider systems with an highly non-linear dynamics and lacking a uniform mathematical description (model). We can also consider situations where the required control action cannot be specified as a local action, and rather a kind of planning is required. Our methodology individuates first a raw optimal controller, then extends it to obtain a more robust one. A case study is presented which considers the well known truck-trailer obstacle avoidance parking problem, in a parking lot with obstacles on it. The complex non-linear dynamics of the truck-trailer system, within the presence of obstacles, makes the parking problem extremely hard. We show how, by our methodology, we can obtain optimal controllers with different degrees of robustness. |
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INSTICC Press |
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Andrade-Cetto, J.; Ferrier, J.-L.; Pereira, J. M. C. D.; Filipe, J. |
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972-8865-59-7 |
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yes |
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Sapienza @ mari @ Dimmtt06 |
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79 |
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