TY  - JOUR
AU  - Fischer, S.
AU  - Ehrig, R.
AU  - Schaefer, S.
AU  - Tronci, E.
AU  - Mancini, T.
AU  - Egli, M.
AU  - Ille, F.
AU  - Krueger, T.H.C.
AU  - Leeners, B.
AU  - Roeblitz, S.
PY  - 2021
DA  - 2021//
TI  - Mathematical Modeling and Simulation Provides Evidence for New Strategies of Ovarian Stimulation
JO  - Frontiers in Endocrinology
SP  - 117
VL  - 12
AB  - New approaches to ovarian stimulation protocols, such as luteal start, random start or double stimulation, allow for flexibility in ovarian stimulation at different phases of the menstrual cycle. It has been proposed that the success of these methods is based on the continuous growth of multiple cohorts ("waves") of follicles throughout the menstrual cycle which leads to the availability of ovarian follicles for ovarian controlled stimulation at several time points. Though several preliminary studies have been published, their scientific evidence has not been considered as being strong enough to integrate these results into routine clinical practice. This work aims at adding further scientific evidence about the efficiency of variable-start protocols and underpinning the theory of follicular waves by using mathematical modeling and numerical simulations. For this purpose, we have modified and coupled two previously published models, one describing the time course of hormones and one describing competitive follicular growth in a normal menstrual cycle. The coupled model is used to test ovarian stimulation protocols in silico. Simulation results show the occurrence of follicles in a wave-like manner during a normal menstrual cycle and qualitatively predict the outcome of ovarian stimulation initiated at different time points of the menstrual cycle.
SN  - 1664-2392
L1  - http://mclab.di.uniroma1.it/publications/papers/fischer/2021/189_Fischer_etal2021.pdf
UR  - https://www.frontiersin.org/article/10.3389/fendo.2021.613048
UR  - https://doi.org/10.3389/fendo.2021.613048
DO  - 10.3389/fendo.2021.613048
N1  - exported from refbase (http://mclab.di.uniroma1.it/publications/show.php?record=189), last updated on Thu, 11 Mar 2021 17:00:54 +0100
ID  - Fischer_etal2021
ER  -