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Author Toni Mancini; Enrico Tronci; Ivano Salvo; Federico Mari; Annalisa Massini; Igor Melatti pdf  doi
openurl 
  Title Computing Biological Model Parameters by Parallel Statistical Model Checking Type Journal Article
  Year 2015 Publication International Work Conference on Bioinformatics and Biomedical Engineering (IWBBIO 2015) Abbreviated Journal  
  Volume (down) 9044 Issue Pages 542-554  
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  Notes Approved no  
  Call Number MCLab @ davi @ Serial 124  
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Author file  doi
openurl 
  Title Charme Type Conference Article
  Year 2003 Publication Lecture Notes in Computer Science Abbreviated Journal  
  Volume (down) 2860 Issue Pages  
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  Corporate Author Thesis  
  Publisher Springer Place of Publication Editor Geist, D.; Tronci, E.  
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  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 3-540-20363-X ISBN Medium  
  Area Expedition Conference  
  Notes Approved yes  
  Call Number Sapienza @ mari @ editor-charme03 Serial 37  
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Author Bucciarelli, Antonio; Salvo, Ivano pdf  doi
openurl 
  Title Totality, Definability and Boolean Circuits Type Journal Article
  Year 1998 Publication Abbreviated Journal  
  Volume (down) 1443 Issue Pages 808-819  
  Keywords  
  Abstract In the type frame originating from the flat domain of boolean values, we single out elements which are hereditarily total. We show that these elements can be defined, up to total equivalence, by sequential programs. The elements of an equivalence class of the totality equivalence relation (totality class) can be seen as different algorithms for computing a given set-theoretic boolean function. We show that the bottom element of a totality class, which is sequential, corresponds to the most eager algorithm, and the top to the laziest one. Finally we suggest a link between size of totality classes and a well known measure of complexity of boolean functions, namely their sensitivity.  
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  Publisher Springer Place of Publication Editor  
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  Notes Approved yes  
  Call Number Sapienza @ mari @ bucciarelli-salvo:98 Serial 70  
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Author Alimguzhin, Vadim; Mari, Federico; Melatti, Igor; Salvo, Ivano; Tronci, Enrico file  url
openurl 
  Title A Map-Reduce Parallel Approach to Automatic Synthesis of Control Software Type Report
  Year 2012 Publication Abbreviated Journal  
  Volume (down) abs/1210.2276 Issue Pages  
  Keywords  
  Abstract Many Control Systems are indeed Software Based Control Systems, i.e. control systems whose controller consists of control software running on a microcontroller device. This motivates investigation on Formal Model Based Design approaches for automatic synthesis of control software.
Available algorithms and tools (e.g., QKS) may require weeks or even months of computation to synthesize control software for large-size systems. This motivates search for parallel algorithms for control software synthesis.
In this paper, we present a map-reduce style parallel algorithm for control software synthesis when the controlled system (plant) is modeled as discrete time linear hybrid system. Furthermore we present an MPI-based implementation PQKS of our algorithm. To the best of our knowledge, this is the first parallel approach for control software synthesis.
We experimentally show effectiveness of PQKS on two classical control synthesis problems: the inverted pendulum and the multi-input buck DC/DC converter. Experiments show that PQKS efficiency is above 65%. As an example, PQKS requires about 16 hours to complete the synthesis of control software for the pendulum on a cluster with 60 processors, instead of the 25 days needed by the sequential algorithm in QKS.
 
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  Corporate Author Thesis  
  Publisher CoRR, Technical Report Place of Publication Editor  
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  Area Expedition Conference  
  Notes Approved yes  
  Call Number Sapienza @ mari @ Serial 101  
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Author Alimguzhin, Vadim; Mari, Federico; Melatti, Igor; Salvo, Ivano; Tronci, Enrico url  openurl
  Title On Model Based Synthesis of Embedded Control Software Type Report
  Year 2012 Publication Abbreviated Journal  
  Volume (down) abs/1207.4474 Issue Pages  
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  Abstract Many Embedded Systems are indeed Software Based Control Systems (SBCSs), that is control systems whose controller consists of control software running on a microcontroller device. This motivates investigation on Formal Model Based Design approaches for control software. Given the formal model of a plant as a Discrete Time Linear Hybrid System and the implementation specifications (that is, number of bits in the Analog-to-Digital (AD) conversion) correct-by-construction control software can be automatically generated from System Level Formal Specifications of the closed loop system (that is, safety and liveness requirements), by computing a suitable finite abstraction of the plant.
With respect to given implementation specifications, the automatically generated code implements a time optimal control strategy (in terms of set-up time), has a Worst Case Execution Time linear in the number of AD bits $b$, but unfortunately, its size grows exponentially with respect to $b$. In many embedded systems, there are severe restrictions on the computational resources (such as memory or computational power) available to microcontroller devices.
This paper addresses model based synthesis of control software by trading system level non-functional requirements (such us optimal set-up time, ripple) with software non-functional requirements (its footprint). Our experimental results show the effectiveness of our approach: for the inverted pendulum benchmark, by using a quantization schema with 12 bits, the size of the small controller is less than 6% of the size of the time optimal one.
 
  Address  
  Corporate Author Thesis  
  Publisher CoRR, Technical Report Place of Publication Editor  
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  Series Editor Series Title Abbreviated Series Title  
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  Area Expedition Conference  
  Notes Approved yes  
  Call Number Sapienza @ mari @ Serial 102  
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Author Alimguzhin, Vadim; Mari, Federico; Melatti, Igor; Salvo, Ivano; Tronci, Enrico url  openurl
  Title Automatic Control Software Synthesis for Quantized Discrete Time Hybrid Systems Type Report
  Year 2012 Publication Abbreviated Journal  
  Volume (down) abs/1207.4098 Issue Pages  
  Keywords  
  Abstract Many Embedded Systems are indeed Software Based Control Systems, that is control systems whose controller consists of control software running on a microcontroller device. This motivates investigation on Formal Model Based Design approaches for automatic synthesis of embedded systems control software. This paper addresses control software synthesis for discrete time nonlinear systems. We present a methodology to overapproximate the dynamics of a discrete time nonlinear hybrid system H by means of a discrete time linear hybrid system L(H), in such a way that controllers for L(H) are guaranteed to be controllers for H. We present experimental results on the inverted pendulum, a challenging and meaningful benchmark in nonlinear Hybrid Systems control.  
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  Corporate Author Thesis  
  Publisher CoRR, Technical Report Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes Approved yes  
  Call Number Sapienza @ mari @ Serial 103  
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Author Mari, Federico; Melatti, Igor; Salvo, Ivano; Tronci, Enrico url  openurl
  Title Model Based Synthesis of Control Software from System Level Formal Specifications Type Report
  Year 2013 Publication Abbreviated Journal  
  Volume (down) abs/1107.5638 Issue Pages  
  Keywords  
  Abstract Many Embedded Systems are indeed Software Based Control Systems, that is control systems whose controller consists of control software running on a microcontroller device. This motivates investigation on Formal Model Based Design approaches for automatic synthesis of embedded systems control software.
We present an algorithm, along with a tool QKS implementing it, that from a formal model (as a Discrete Time Linear Hybrid System) of the controlled system (plant), implementation specifications (that is, number of bits in the Analog-to-Digital, AD, conversion) and System Level Formal Specifications (that is, safety and liveness requirements for the closed loop system) returns correct-by-construction control software that has a Worst Case Execution Time (WCET) linear in the number of AD bits and meets the given specifications.
We show feasibility of our approach by presenting experimental results on using it to synthesize control software for a buck DC-DC converter, a widely used mixed-mode analog circuit, and for the inverted pendulum.
 
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  Publisher CoRR, Technical Report Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes Approved yes  
  Call Number Sapienza @ mari @ Serial 104  
Permanent link to this record
 

 
Author Mari, Federico; Melatti, Igor; Salvo, Ivano; Tronci, Enrico url  openurl
  Title From Boolean Functional Equations to Control Software Type Report
  Year 2011 Publication Abbreviated Journal  
  Volume (down) abs/1106.0468 Issue Pages  
  Keywords  
  Abstract Many software as well digital hardware automatic synthesis methods define the set of implementations meeting the given system specifications with a boolean relation K. In such a context a fundamental step in the software (hardware) synthesis process is finding effective solutions to the functional equation defined by K. This entails finding a (set of) boolean function(s) F (typically represented using OBDDs, Ordered Binary Decision Diagrams) such that: 1) for all x for which K is satisfiable, K(x, F(x)) = 1 holds; 2) the implementation of F is efficient with respect to given implementation parameters such as code size or execution time. While this problem has been widely studied in digital hardware synthesis, little has been done in a software synthesis context. Unfortunately the approaches developed for hardware synthesis cannot be directly used in a software context. This motivates investigation of effective methods to solve the above problem when F has to be implemented with software. In this paper we present an algorithm that, from an OBDD representation for K, generates a C code implementation for F that has the same size as the OBDD for F and a WCET (Worst Case Execution Time) at most O(nr), being n = |x| the number of arguments of functions in F and r the number of functions in F.  
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  Corporate Author Thesis  
  Publisher CoRR, Technical Report Place of Publication Editor  
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  Series Editor Series Title Abbreviated Series Title  
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  Area Expedition Conference  
  Notes Approved yes  
  Call Number Sapienza @ mari @ Serial 105  
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Author Mari, Federico; Melatti, Igor; Salvo, Ivano; Tronci, Enrico url  openurl
  Title Quantized Feedback Control Software Synthesis from System Level Formal Specifications for Buck DC/DC Converters Type Report
  Year 2011 Publication Abbreviated Journal  
  Volume (down) abs/1105.5640 Issue Pages  
  Keywords  
  Abstract Many Embedded Systems are indeed Software Based Control Systems (SBCSs), that is control systems whose controller consists of control software running on a microcontroller device. This motivates investigation on Formal Model Based Design approaches for automatic synthesis of SBCS control software. In previous works we presented an algorithm, along with a tool QKS implementing it, that from a formal model (as a Discrete Time Linear Hybrid System, DTLHS) of the controlled system (plant), implementation specifications (that is, number of bits in the Analog-to-Digital, AD, conversion) and System Level Formal Specifications (that is, safety and liveness requirements for the closed loop system) returns correct-by-construction control software that has a Worst Case Execution Time (WCET) linear in the number of AD bits and meets the given specifications. In this technical report we present full experimental results on using it to synthesize control software for two versions of buck DC-DC converters (single-input and multi-input), a widely used mixed-mode analog circuit.  
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  Corporate Author Thesis  
  Publisher CoRR, Technical Report Place of Publication Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes Approved yes  
  Call Number Sapienza @ mari @ Serial 106  
Permanent link to this record
 

 
Author Sinisi, S.; Alimguzhin, V.; Mancini, T.; Tronci, E.; Mari, F.; Leeners, B. pdf  doi
openurl 
  Title Optimal Personalised Treatment Computation through In Silico Clinical Trials on Patient Digital Twins Type Journal Article
  Year 2020 Publication Abbreviated Journal Fundamenta Informaticae  
  Volume (down) 174 Issue Pages 283-310  
  Keywords Artificial Intelligence; Virtual Physiological Human; In Silico Clinical Trials; Simulation; Personalised Medicine; In Silico Treatment Optimisation  
  Abstract In Silico Clinical Trials (ISCT), i.e. clinical experimental campaigns carried out by means of computer simulations, hold the promise to decrease time and cost for the safety and efficacy assessment of pharmacological treatments, reduce the need for animal and human testing, and enable precision medicine. In this paper we present methods and an algorithm that, by means of extensive computer simulation-based experimental campaigns (ISCT) guided by intelligent search, optimise a pharmacological treatment for an individual patient (precision medicine ). We show the effectiveness of our approach on a case study involving a real pharmacological treatment, namely the downregulation phase of a complex clinical protocol for assisted reproduction in humans.  
  Address  
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  Publisher IOS Press Place of Publication Editor  
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  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1875-8681 ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number MCLab @ davi @ Serial 187  
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