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S. Fischer, R. Ehrig, S. Schaefer, E. Tronci, T. Mancini, M. Egli, F. Ille, T. H. C. Krueger, B. Leeners, and S. Roeblitz. "Mathematical Modeling and Simulation Provides Evidence for New Strategies of Ovarian Stimulation." Frontiers in Endocrinology 12 (2021): 117. ISSN: 1664-2392. DOI: 10.3389/fendo.2021.613048.
Abstract: New approaches to ovarian stimulation protocols, such as luteal start, random start or double stimulation, allow for flexibility in ovarian stimulation at different phases of the menstrual cycle. It has been proposed that the success of these methods is based on the continuous growth of multiple cohorts (“waves”) of follicles throughout the menstrual cycle which leads to the availability of ovarian follicles for ovarian controlled stimulation at several time points. Though several preliminary studies have been published, their scientific evidence has not been considered as being strong enough to integrate these results into routine clinical practice. This work aims at adding further scientific evidence about the efficiency of variable-start protocols and underpinning the theory of follicular waves by using mathematical modeling and numerical simulations. For this purpose, we have modified and coupled two previously published models, one describing the time course of hormones and one describing competitive follicular growth in a normal menstrual cycle. The coupled model is used to test ovarian stimulation protocols in silico. Simulation results show the occurrence of follicles in a wave-like manner during a normal menstrual cycle and qualitatively predict the outcome of ovarian stimulation initiated at different time points of the menstrual cycle.
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I. Melatti, F. Mari, T. Mancini, M. Prodanovic, and E. Tronci. "A Two-Layer Near-Optimal Strategy for Substation Constraint Management via Home Batteries." IEEE Transactions on Industrial Electronics (2021): 1. Notes: To appear. DOI: 10.1109/TIE.2021.3102431.
Abstract: Within electrical distribution networks, substation constraints management requires that aggregated power demand from residential users is kept within suitable bounds. Efficiency of substation constraints management can be measured as the reduction of constraints violations w.r.t. unmanaged demand. Home batteries hold the promise of enabling efficient and user-oblivious substation constraints management. Centralized control of home batteries would achieve optimal efficiency. However, it is hardly acceptable by users, since service providers (e.g., utilities or aggregators) would directly control batteries at user premises. Unfortunately, devising efficient hierarchical control strategies, thus overcoming the above problem, is far from easy. We present a novel two-layer control strategy for home batteries that avoids direct control of home devices by the service provider and at the same time yields near-optimal substation constraints management efficiency. Our simulation results on field data from 62 households in Denmark show that the substation constraints management efficiency achieved with our approach is at least 82% of the one obtained with a theoretical optimal centralized strategy.
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T. Mancini, I. Melatti, and E. Tronci. "Any-horizon uniform random sampling and enumeration of constrained scenarios for simulation-based formal verification." IEEE Transactions on Software Engineering (2021): 1. ISSN: 1939-3520. Notes: To appear. DOI: 10.1109/TSE.2021.3109842.
Abstract: Model-based approaches to the verification of non-terminating Cyber-Physical Systems (CPSs) usually rely on numerical simulation of the System Under Verification (SUV) model under input scenarios of possibly varying duration, chosen among those satisfying given constraints. Such constraints typically stem from requirements (or assumptions) on the SUV inputs and its operational environment as well as from the enforcement of additional conditions aiming at, e.g., prioritising the (often extremely long) verification activity, by, e.g., focusing on scenarios explicitly exercising selected requirements, or avoiding </i>vacuity</i> in their satisfaction. In this setting, the possibility to efficiently sample at random (with a known distribution, e.g., uniformly) within, or to efficiently enumerate (possibly in a uniformly random order) scenarios among those satisfying all the given constraints is a key enabler for the practical viability of the verification process, e.g., via simulation-based statistical model checking. Unfortunately, in case of non-trivial combinations of constraints, iterative approaches like Markovian random walks in the space of sequences of inputs in general fail in extracting scenarios according to a given distribution (e.g., uniformly), and can be very inefficient to produce at all scenarios that are both legal (with respect to SUV assumptions) and of interest (with respect to the additional constraints). For example, in our case studies, up to 91% of the scenarios generated using such iterative approaches would need to be neglected. In this article, we show how, given a set of constraints on the input scenarios succinctly defined by multiple finite memory monitors, a data structure (scenario generator) can be synthesised, from which any-horizon scenarios satisfying the input constraints can be efficiently extracted by (possibly uniform) random sampling or (randomised) enumeration. Our approach enables seamless support to virtually all simulation-based approaches to CPS verification, ranging from simple random testing to statistical model checking and formal (i.e., exhaustive) verification, when a suitable bound on the horizon or an iterative horizon enlargement strategy is defined, as in the spirit of bounded model checking.
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Enrico Tronci. "Introductory Paper." Sttt 8, no. 4-5 (2006): 355–358. DOI: 10.1007/s10009-005-0212-y.
Abstract: In todayââ¬â¢s competitive market designing of digital systems (hardware as well as software) faces tremendous challenges. In fact, notwithstanding an ever decreasing project budget, time to market and product lifetime, designers are faced with an ever increasing system complexity and customer expected quality. The above situation calls for better and better formal verification techniques at all steps of the design flow. This special issue is devoted to publishing revised versions of contributions first presented at the 12th Advanced Research Working Conference on Correct Hardware Design and Verification Methods (CHARME) held 21Ãâ24 October 2003 in Lââ¬â¢Aquila, Italy. Authors of well regarded papers from CHARMEââ¬â¢03 were invited to submit to this special issue. All papers included here have been suitably extended and have undergone an independent round of reviewing.
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Giuseppe Della Penna, Daniele Magazzeni, Alberto Tofani, Benedetto Intrigila, Igor Melatti, and Enrico Tronci. "Automated Generation Of Optimal Controllers Through Model Checking Techniques." In Informatics in Control Automation and Robotics. Selected Papers from ICINCO 2006, 107–119. Springer, 2008. DOI: 10.1007/978-3-540-79142-3_10.
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Novella Bartolini, and Enrico Tronci. "On Optimizing Service Availability of an Internet Based Architecture for Infrastructure Protection." In Cnip., 2006.
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Michele Cecconi, and Enrico Tronci. "Requirements Formalization and Validation for a Telecommunication Equipment Protection Switcher." In Hase. IEEE Computer Society, 2000. ISSN: 0-7695-0927-4. DOI: 10.1109/HASE.2000.895456.
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Amedeo Cesta, Alberto Finzi, Simone Fratini, Andrea Orlandini, and Enrico Tronci. "Merging Planning, Scheduling & Verification – A Preliminary Analysis." In In Proc. of 10th ESA Workshop on Advanced Space Technologies for Robotics and Automation (ASTRA)., 2008.
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Amedeo Cesta, Alberto Finzi, Simone Fratini, Andrea Orlandini, and Enrico Tronci. "Validation and Verification Issues in a Timeline-based Planning System." In In E-Proc. of ICAPS Workshop on Knowledge Engineering for Planning and Scheduling., 2008.
Abstract: One of the key points to take into account to foster effective introduction of AI planning and scheduling systems in real world is to develop end user trust in the related technologies. Automated planning and scheduling systems often brings solutions to the users which are neither ââ¬Åobviousââ¬Â nor immediately acceptable for them. This is due to the ability of these tools to take into account quite an amount of temporal and causal constraints and to employ resolution processes often designed to optimize the solution with respect to non trivial evaluation functions. To increase technology trust, the study of tools for verifying and validating plans and schedules produced by AI systems might be instrumental. In general, validation and verification techniques represent a needed complementary technology in developing domain independent architectures for automated problem solving. This paper presents a preliminary report of the issues concerned with the use of two software tools for formal verification of finite state systems to the validation of the solutions produced by MrSPOCK, a recent effort for building a timeline based planning tool in an ESA project.
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Amedeo Cesta, Alberto Finzi, Simone Fratini, Andrea Orlandini, and Enrico Tronci. "Verifying Flexible Timeline-based Plans." In E-Proc. of ICAPS Workshop on Validation and Verification of Planning and Scheduling Systems., 2009.
Abstract: The synthesis of flexible temporal plans has demonstrated wide applications possibilities in heterogeneous domains. We are currently studying the connection between plan generation and execution from the particular perspective of verifying a flexible plan before actual execution. This paper explores how a model-checking verification tool, based on UPPAAL-TIGA, is suitable for verifying flexible temporal plans. We first describe the formal model, the formalism, and the verification method. Furthermore we discuss our own approach and some preliminary empirical results using a real-world case study.
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