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T. Mancini, A. Massini, and E. Tronci. "Parallelization of Cycle-Based Logic Simulation." Parallel Processing Letters 27, no. 02 (2017). DOI: 10.1142/S0129626417500037.
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T. Mancini, F. Mari, I. Melatti, I. Salvo, E. Tronci, J. Gruber, B. Hayes, M. Prodanovic, and L. Elmegaard. "Parallel Statistical Model Checking for Safety Verification in Smart Grids." In 2018 IEEE International Conference on Communications, Control, and Computing Technologies for Smart Grids (SmartGridComm), 1–6., 2018. DOI: 10.1109/SmartGridComm.2018.8587416.
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Igor Melatti, Robert Palmer, Geoffrey Sawaya, Yu Yang, Robert Mike Kirby, and Ganesh Gopalakrishnan. "Parallel and distributed model checking in Eddy." Int. J. Softw. Tools Technol. Transf. 11, no. 1 (2009): 13–25. Springer-Verlag. ISSN: 1433-2779. DOI: 10.1007/s10009-008-0094-x.
Abstract: Model checking of safety properties can be scaled up by pooling the CPU and memory resources of multiple computers. As compute clusters containing 100s of nodes, with each node realized using multi-core (e.g., 2) CPUs will be widespread, a model checker based on the parallel (shared memory) and distributed (message passing) paradigms will more efficiently use the hardware resources. Such a model checker can be designed by having each node employ two shared memory threads that run on the (typically) two CPUs of a node, with one thread responsible for state generation, and the other for efficient communication, including (1) performing overlapped asynchronous message passing, and (2) aggregating the states to be sent into larger chunks in order to improve communication network utilization. We present the design details of such a novel model checking architecture called Eddy. We describe the design rationale, details of how the threads interact and yield control, exchange messages, as well as detect termination. We have realized an instance of this architecture for the Murphi modeling language. Called Eddy_Murphi, we report its performance over the number of nodes as well as communication parameters such as those controlling state aggregation. Nearly linear reduction of compute time with increasing number of nodes is observed. Our thread task partition is done in such a way that it is modular, easy to port across different modeling languages, and easy to tune across a variety of platforms.
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Igor Melatti, Robert Palmer, Geoffrey Sawaya, Yu Yang, Robert Mike Kirby, and Ganesh Gopalakrishnan. "Parallel and Distributed Model Checking in Eddy." In Model Checking Software, 13th International SPIN Workshop, Vienna, Austria, March 30 – April 1, 2006, Proceedings, edited by A. Valmari, 108–125. Lecture Notes in Computer Science 3925. Springer - Verlag, 2006. ISSN: 0302-9743. ISBN: 978-3-540-33102-5. DOI: 10.1007/11691617_7.
Abstract: Model checking of safety properties can be scaled up by pooling the CPU and memory resources of multiple computers. As compute clusters containing 100s of nodes, with each node realized using multi-core (e.g., 2) CPUs will be widespread, a model checker based on the parallel (shared memory) and distributed (message passing) paradigms will more efficiently use the hardware resources. Such a model checker can be designed by having each node employ two shared memory threads that run on the (typically) two CPUs of a node, with one thread responsible for state generation, and the other for efficient communication, including (i) performing overlapped asynchronous message passing, and (ii) aggregating the states to be sent into larger chunks in order to improve communication network utilization. We present the design details of such a novel model checking architecture called Eddy. We describe the design rationale, details of how the threads interact and yield control, exchange messages, as well as detect termination. We have realized an instance of this architecture for the Murphi modeling language. Called Eddy_Murphi, we report its performance over the number of nodes as well as communication parameters such as those controlling state aggregation. Nearly linear reduction of compute time with increasing number of nodes is observed. Our thread task partition is done in such a way that it is modular, easy to port across different modeling languages, and easy to tune across a variety of platforms.
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S. Sinisi, V. Alimguzhin, T. Mancini, E. Tronci, F. Mari, and B. Leeners. "Optimal Personalised Treatment Computation through In Silico Clinical Trials on Patient Digital Twins." Fundamenta Informaticae 174 (2020): 283–310. IOS Press. ISSN: 1875-8681. DOI: 10.3233/FI-2020-1943.
Abstract: In Silico Clinical Trials (ISCT), i.e. clinical experimental campaigns carried out by means of computer simulations, hold the promise to decrease time and cost for the safety and efficacy assessment of pharmacological treatments, reduce the need for animal and human testing, and enable precision medicine. In this paper we present methods and an algorithm that, by means of extensive computer simulation-based experimental campaigns (ISCT) guided by intelligent search, optimise a pharmacological treatment for an individual patient (precision medicine ). We show the effectiveness of our approach on a case study involving a real pharmacological treatment, namely the downregulation phase of a complex clinical protocol for assisted reproduction in humans.
Keywords: Artificial Intelligence; Virtual Physiological Human; In Silico Clinical Trials; Simulation; Personalised Medicine; In Silico Treatment Optimisation
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Enrico Tronci. "Optimal Finite State Supervisory Control." In CDC '96: Proceedings of the 35th IEEE International Conference on Decision and Control. Washington, DC, USA: IEEE Computer Society, 1996. DOI: 10.1109/CDC.1996.572981.
Abstract: Supervisory Controllers are Discrete Event Dynamic Systems (DEDSs) forming the discrete core of a Hybrid Control System. We address the problem of automatic synthesis of Optimal Finite State Supervisory Controllers (OSCs). We show that Boolean First Order Logic (BFOL) and Binary Decision Diagrams (BDDs) are an effective methodological and practical framework for Optimal Finite State Supervisory Control. Using BFOL programs (i.e. systems of boolean functional equations) and BDDs we give a symbolic (i.e. BDD based) algorithm for automatic synthesis of OSCs. Our OSC synthesis algorithm can handle arbitrary sets of final states as well as plant transition relations containing loops and uncontrollable events (e.g. failures). We report on experimental results on the use of our OSC synthesis algorithm to synthesize a C program implementing a minimum fuel OSC for two autonomous vehicles moving on a 4 x 4 grid.
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T. Mancini, E. Tronci, A. Scialanca, F. Lanciotti, A. Finzi, R. Guarneri, and S. Di Pompeo. "Optimal Fault-Tolerant Placement of Relay Nodes in a Mission Critical Wireless Network." In 25th RCRA International Workshop on “Experimental Evaluation of Algorithms for Solving Problems with Combinatorial Explosion” (RCRA 2018)., 2018. DOI: 10.29007/grw9.
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Vadim Alimguzhin, Federico Mari, Igor Melatti, Ivano Salvo, and Enrico Tronci. "On-the-Fly Control Software Synthesis." In Proceedings of International SPIN Symposium on Model Checking of Software (SPIN 2013), 61–80. Lecture Notes in Computer Science 7976. Springer - Verlag, 2013. ISSN: 0302-9743. ISBN: 978-3-642-39175-0. DOI: 10.1007/978-3-642-39176-7_5.
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Flavio Chierichetti, Silvio Lattanzi, Federico Mari, and Alessandro Panconesi. "On Placing Skips Optimally in Expectation." In Web Search and Web Data Mining (WSDM 2008), edited by M. Najork, A. Z. Broder and S. Chakrabarti, 15–24. Acm, 2008. DOI: 10.1145/1341531.1341537.
Abstract: We study the problem of optimal skip placement in an inverted list. Assuming the query distribution to be known in advance, we formally prove that an optimal skip placement can be computed quite efficiently. Our best algorithm runs in time O(n log n), n being the length of the list. The placement is optimal in the sense that it minimizes the expected time to process a query. Our theoretical results are matched by experiments with a real corpus, showing that substantial savings can be obtained with respect to the tra- ditional skip placement strategy, that of placing consecutive skips, each spanning sqrt(n) many locations.
Keywords: Information Retrieval
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Novella Bartolini, and Enrico Tronci. "On Optimizing Service Availability of an Internet Based Architecture for Infrastructure Protection." In Cnip., 2006.
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