Toni Mancini, Enrico Tronci, Ivano Salvo, Federico Mari, Annalisa Massini, and Igor Melatti. "Computing Biological Model Parameters by Parallel Statistical Model Checking." International Work Conference on Bioinformatics and Biomedical Engineering (IWBBIO 2015) 9044 (2015): 542–554. DOI: 10.1007/9783319164809_52.

"Charme." In Lecture Notes in Computer Science, edited by D. Geist and E. Tronci. Vol. 2860. Springer, 2003. ISSN: 354020363X. DOI: 10.1007/b93958.

Antonio Bucciarelli, and Ivano Salvo. "Totality, Definability and Boolean Circuits." 1443 (1998): 808–819. Springer. DOI: 10.1007/BFb0055104.
Abstract: In the type frame originating from the flat domain of boolean values, we single out elements which are hereditarily total. We show that these elements can be defined, up to total equivalence, by sequential programs. The elements of an equivalence class of the totality equivalence relation (totality class) can be seen as different algorithms for computing a given settheoretic boolean function. We show that the bottom element of a totality class, which is sequential, corresponds to the most eager algorithm, and the top to the laziest one. Finally we suggest a link between size of totality classes and a well known measure of complexity of boolean functions, namely their sensitivity.

Vadim Alimguzhin, Federico Mari, Igor Melatti, Ivano Salvo, and Enrico Tronci. A MapReduce Parallel Approach to Automatic Synthesis of Control Software. Vol. abs/1210.2276. CoRR, Technical Report, 2012.
Abstract: Many Control Systems are indeed Software Based Control Systems, i.e. control systems whose controller consists of control software running on a microcontroller device. This motivates investigation on Formal Model Based Design approaches for automatic synthesis of control software.
Available algorithms and tools (e.g., QKS) may require weeks or even months of computation to synthesize control software for largesize systems. This motivates search for parallel algorithms for control software synthesis.
In this paper, we present a mapreduce style parallel algorithm for control software synthesis when the controlled system (plant) is modeled as discrete time linear hybrid system. Furthermore we present an MPIbased implementation PQKS of our algorithm. To the best of our knowledge, this is the first parallel approach for control software synthesis.
We experimentally show effectiveness of PQKS on two classical control synthesis problems: the inverted pendulum and the multiinput buck DC/DC converter. Experiments show that PQKS efficiency is above 65%. As an example, PQKS requires about 16 hours to complete the synthesis of control software for the pendulum on a cluster with 60 processors, instead of the 25 days needed by the sequential algorithm in QKS.

Vadim Alimguzhin, Federico Mari, Igor Melatti, Ivano Salvo, and Enrico Tronci. On Model Based Synthesis of Embedded Control Software. Vol. abs/1207.4474. CoRR, Technical Report, 2012.
Abstract: Many Embedded Systems are indeed Software Based Control Systems (SBCSs), that is control systems whose controller consists of control software running on a microcontroller device. This motivates investigation on Formal Model Based Design approaches for control software. Given the formal model of a plant as a Discrete Time Linear Hybrid System and the implementation specifications (that is, number of bits in the AnalogtoDigital (AD) conversion) correctbyconstruction control software can be automatically generated from System Level Formal Specifications of the closed loop system (that is, safety and liveness requirements), by computing a suitable finite abstraction of the plant.
With respect to given implementation specifications, the automatically generated code implements a time optimal control strategy (in terms of setup time), has a Worst Case Execution Time linear in the number of AD bits $b$, but unfortunately, its size grows exponentially with respect to $b$. In many embedded systems, there are severe restrictions on the computational resources (such as memory or computational power) available to microcontroller devices.
This paper addresses model based synthesis of control software by trading system level nonfunctional requirements (such us optimal setup time, ripple) with software nonfunctional requirements (its footprint). Our experimental results show the effectiveness of our approach: for the inverted pendulum benchmark, by using a quantization schema with 12 bits, the size of the small controller is less than 6% of the size of the time optimal one.

Vadim Alimguzhin, Federico Mari, Igor Melatti, Ivano Salvo, and Enrico Tronci. Automatic Control Software Synthesis for Quantized Discrete Time Hybrid Systems. Vol. abs/1207.4098. CoRR, Technical Report, 2012.
Abstract: Many Embedded Systems are indeed Software Based Control Systems, that is control systems whose controller consists of control software running on a microcontroller device. This motivates investigation on Formal Model Based Design approaches for automatic synthesis of embedded systems control software. This paper addresses control software synthesis for discrete time nonlinear systems. We present a methodology to overapproximate the dynamics of a discrete time nonlinear hybrid system H by means of a discrete time linear hybrid system L(H), in such a way that controllers for L(H) are guaranteed to be controllers for H. We present experimental results on the inverted pendulum, a challenging and meaningful benchmark in nonlinear Hybrid Systems control.

Federico Mari, Igor Melatti, Ivano Salvo, and Enrico Tronci. Model Based Synthesis of Control Software from System Level Formal Specifications. Vol. abs/1107.5638. CoRR, Technical Report, 2013.
Abstract: Many Embedded Systems are indeed Software Based Control Systems, that is control systems whose controller consists of control software running on a microcontroller device. This motivates investigation on Formal Model Based Design approaches for automatic synthesis of embedded systems control software.
We present an algorithm, along with a tool QKS implementing it, that from a formal model (as a Discrete Time Linear Hybrid System) of the controlled system (plant), implementation specifications (that is, number of bits in the AnalogtoDigital, AD, conversion) and System Level Formal Specifications (that is, safety and liveness requirements for the closed loop system) returns correctbyconstruction control software that has a Worst Case Execution Time (WCET) linear in the number of AD bits and meets the given specifications.
We show feasibility of our approach by presenting experimental results on using it to synthesize control software for a buck DCDC converter, a widely used mixedmode analog circuit, and for the inverted pendulum.

Federico Mari, Igor Melatti, Ivano Salvo, and Enrico Tronci. From Boolean Functional Equations to Control Software. Vol. abs/1106.0468. CoRR, Technical Report, 2011.
Abstract: Many software as well digital hardware automatic synthesis methods define the set of implementations meeting the given system specifications with a boolean relation K. In such a context a fundamental step in the software (hardware) synthesis process is finding effective solutions to the functional equation defined by K. This entails finding a (set of) boolean function(s) F (typically represented using OBDDs, Ordered Binary Decision Diagrams) such that: 1) for all x for which K is satisfiable, K(x, F(x)) = 1 holds; 2) the implementation of F is efficient with respect to given implementation parameters such as code size or execution time. While this problem has been widely studied in digital hardware synthesis, little has been done in a software synthesis context. Unfortunately the approaches developed for hardware synthesis cannot be directly used in a software context. This motivates investigation of effective methods to solve the above problem when F has to be implemented with software. In this paper we present an algorithm that, from an OBDD representation for K, generates a C code implementation for F that has the same size as the OBDD for F and a WCET (Worst Case Execution Time) at most O(nr), being n = x the number of arguments of functions in F and r the number of functions in F.

Federico Mari, Igor Melatti, Ivano Salvo, and Enrico Tronci. Quantized Feedback Control Software Synthesis from System Level Formal Specifications for Buck DC/DC Converters. Vol. abs/1105.5640. CoRR, Technical Report, 2011.
Abstract: Many Embedded Systems are indeed Software Based Control Systems (SBCSs), that is control systems whose controller consists of control software running on a microcontroller device. This motivates investigation on Formal Model Based Design approaches for automatic synthesis of SBCS control software. In previous works we presented an algorithm, along with a tool QKS implementing it, that from a formal model (as a Discrete Time Linear Hybrid System, DTLHS) of the controlled system (plant), implementation specifications (that is, number of bits in the AnalogtoDigital, AD, conversion) and System Level Formal Specifications (that is, safety and liveness requirements for the closed loop system) returns correctbyconstruction control software that has a Worst Case Execution Time (WCET) linear in the number of AD bits and meets the given specifications. In this technical report we present full experimental results on using it to synthesize control software for two versions of buck DCDC converters (singleinput and multiinput), a widely used mixedmode analog circuit.

S. Sinisi, V. Alimguzhin, T. Mancini, E. Tronci, F. Mari, and B. Leeners. "Optimal Personalised Treatment Computation through In Silico Clinical Trials on Patient Digital Twins." Fundamenta Informaticae 174 (2020): 283–310. IOS Press. ISSN: 18758681. DOI: 10.3233/FI20201943.
Abstract: In Silico Clinical Trials (ISCT), i.e. clinical experimental campaigns carried out by means of computer simulations, hold the promise to decrease time and cost for the safety and efficacy assessment of pharmacological treatments, reduce the need for animal and human testing, and enable precision medicine. In this paper we present methods and an algorithm that, by means of extensive computer simulationbased experimental campaigns (ISCT) guided by intelligent search, optimise a pharmacological treatment for an individual patient (precision medicine ). We show the effectiveness of our approach on a case study involving a real pharmacological treatment, namely the downregulation phase of a complex clinical protocol for assisted reproduction in humans.
Keywords: Artificial Intelligence; Virtual Physiological Human; In Silico Clinical Trials; Simulation; Personalised Medicine; In Silico Treatment Optimisation
