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	Author	Sinisi, S.; Alimguzhin, V.; Mancini, T.; Tronci, E.; Mari, F.; Leeners, B.
	Title	Optimal Personalised Treatment Computation through In Silico Clinical Trials on Patient Digital Twins			Type	Journal Article
	Year	2020	Publication		Abbreviated Journal	Fundamenta Informaticae
	Volume	174	Issue		Pages	283-310
	Keywords	Artificial Intelligence; Virtual Physiological Human; In Silico Clinical Trials; Simulation; Personalised Medicine; In Silico Treatment Optimisation
	Abstract	In Silico Clinical Trials (ISCT), i.e. clinical experimental campaigns carried out by means of computer simulations, hold the promise to decrease time and cost for the safety and efficacy assessment of pharmacological treatments, reduce the need for animal and human testing, and enable precision medicine. In this paper we present methods and an algorithm that, by means of extensive computer simulation-based experimental campaigns (ISCT) guided by intelligent search, optimise a pharmacological treatment for an individual patient (precision medicine ). We show the effectiveness of our approach on a case study involving a real pharmacological treatment, namely the downregulation phase of a complex clinical protocol for assisted reproduction in humans.
	Address
	Corporate Author				Thesis
	Publisher	IOS Press	Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN	1875-8681	ISBN		Medium
	Area		Expedition		Conference
	Notes				Approved	no
	Call Number	MCLab @ davi @			Serial	187
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	Author	Chen, Q.M.; Finzi, A.; Mancini, T.; Melatti, I.; Tronci, E.
	Title	MILP, Pseudo-Boolean, and OMT Solvers for Optimal Fault-Tolerant Placements of Relay Nodes in Mission Critical Wireless Networks			Type	Journal Article
	Year	2020	Publication		Abbreviated Journal	Fundamenta Informaticae
	Volume	174	Issue		Pages	229-258
	Keywords
	Abstract	In critical infrastructures like airports, much care has to be devoted in protecting radio communication networks from external electromagnetic interference. Protection of such mission-critical radio communication networks is usually tackled by exploiting radiogoniometers: at least three suitably deployed radiogoniometers, and a gateway gathering information from them, permit to monitor and localise sources of electromagnetic emissions that are not supposed to be present in the monitored area. Typically, radiogoniometers are connected to the gateway through relay nodes . As a result, some degree of fault-tolerance for the network of relay nodes is essential in order to offer a reliable monitoring. On the other hand, deployment of relay nodes is typically quite expensive. As a result, we have two conflicting requirements: minimise costs while guaranteeing a given fault-tolerance. In this paper, we address the problem of computing a deployment for relay nodes that minimises the overall cost while at the same time guaranteeing proper working of the network even when some of the relay nodes (up to a given maximum number) become faulty (fault-tolerance ). We show that, by means of a computation-intensive pre-processing on a HPC infrastructure, the above optimisation problem can be encoded as a 0/1 Linear Program, becoming suitable to be approached with standard Artificial Intelligence reasoners like MILP, PB-SAT, and SMT/OMT solvers. Our problem formulation enables us to present experimental results comparing the performance of these three solving technologies on a real case study of a relay node network deployment in areas of the Leonardo da Vinci Airport in Rome, Italy.
	Address
	Corporate Author				Thesis
	Publisher	IOS Press	Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN	1875-8681	ISBN		Medium
	Area		Expedition		Conference
	Notes				Approved	no
	Call Number	MCLab @ davi @			Serial	188
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	Author	Mancini, T.; Mari, F.; Massini, A.; Melatti, I.; Tronci, E.
	Title	SyLVaaS: System Level Formal Verification as a Service			Type	Journal Article
	Year	2016	Publication	Fundamenta Informaticae	Abbreviated Journal
	Volume	149	Issue	1-2	Pages	101-132
	Keywords
	Abstract
	Address
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN		ISBN		Medium
	Area		Expedition		Conference
	Notes				Approved	no
	Call Number	MCLab @ davi @ DBLP:journals/fuin/ManciniMMMT16			Serial	160
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	Author	Cesta, Amedeo; Fratini, Simone; Orlandini, Andrea; Finzi, Alberto; Tronci, Enrico
	Title	Flexible Plan Verification: Feasibility Results			Type	Journal Article
	Year	2011	Publication	Fundamenta Informaticae	Abbreviated Journal
	Volume	107	Issue	2	Pages	111-137
	Keywords
	Abstract
	Address
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN		ISBN		Medium
	Area		Expedition		Conference
	Notes				Approved	yes
	Call Number	Sapienza @ mari @ fi11			Serial	15
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	Author	Mancini, T.; Tronci, E.; Scialanca, A.; Lanciotti, F.; Finzi, A.; Guarneri, R.; Di Pompeo, S.
	Title	Optimal Fault-Tolerant Placement of Relay Nodes in a Mission Critical Wireless Network			Type	Conference Article
	Year	2018	Publication	25th RCRA International Workshop on “Experimental Evaluation of Algorithms for Solving Problems with Combinatorial Explosion” (RCRA 2018)	Abbreviated Journal
	Volume		Issue		Pages
	Keywords
	Abstract
	Address
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN		ISBN		Medium
	Area		Expedition		Conference
	Notes				Approved	no
	Call Number	MCLab @ davi @			Serial	174
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	Author	Mancini, T.; Mari, F.; Massini, A.; Melatti, I.; Salvo, I.; Sinisi, S.; Tronci, E.; Ehrig, R.; RÃ¶blitz, S.; Leeners, B.
	Title	Computing Personalised Treatments through In Silico Clinical Trials. A Case Study on Downregulation in Assisted Reproduction			Type	Conference Article
	Year	2018	Publication	25th RCRA International Workshop on “Experimental Evaluation of Algorithms for Solving Problems with Combinatorial Explosion” (RCRA 2018)	Abbreviated Journal
	Volume		Issue		Pages
	Keywords
	Abstract
	Address
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN		ISBN		Medium
	Area		Expedition		Conference
	Notes				Approved	no
	Call Number	MCLab @ davi @			Serial	175
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	Author	Verzino Giovanni ; Cavaliere, Federico; Mari, Federico; Melatti, Igor; Minei, Giovanni; Salvo, Ivano; Yushtein, Yuri; Tronci, Enrico
	Title	Model checking driven simulation of sat procedures			Type	Conference Article
	Year	2012	Publication	Proceedings of 12th International Conference on Space Operations (SpaceOps 2012)	Abbreviated Journal	International Conference on Space Operations
	Volume		Issue		Pages
	Keywords
	Abstract
	Address
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN		ISBN		Medium
	Area		Expedition		Conference
	Notes				Approved	no
	Call Number	Sapienza @ melatti @			Serial	117
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	Author	Alimguzhin, Vadim; Mari, Federico; Melatti, Igor; Salvo, Ivano; Tronci, Enrico
	Title	On Model Based Synthesis of Embedded Control Software			Type	Conference Article
	Year	2012	Publication	Proceedings of the 12th International Conference on Embedded Software, EMSOFT 2012, part of the Eighth Embedded Systems Week, ESWeek 2012, Tampere, Finland, October 7-12, 2012	Abbreviated Journal
	Volume		Issue		Pages	227-236
	Keywords
	Abstract
	Address
	Corporate Author				Thesis
	Publisher	ACM	Place of Publication		Editor	Ahmed Jerraya and Luca P. Carloni and Florence Maraninchi and John Regehr
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN		ISBN	978-1-4503-1425-1	Medium
	Area		Expedition		Conference
	Notes	Techreport version can be found at arxiv.org			Approved	yes
	Call Number	Sapienza @ mari @ emsoft12			Serial	97
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	Author	Mancini, T.; Massini, A.; Tronci, E.
	Title	Parallelization of Cycle-Based Logic Simulation			Type	Journal Article
	Year	2017	Publication	Parallel Processing Letters	Abbreviated Journal
	Volume	27	Issue	02	Pages
	Keywords
	Abstract
	Address
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN		ISBN		Medium
	Area		Expedition		Conference
	Notes				Approved	no
	Call Number	MCLab @ davi @			Serial	166
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	Author	Piperno, Adolfo; Tronci, Enrico
	Title	Regular Systems of Equations in λ-calculus			Type	Journal Article
	Year	1990	Publication	Int. J. Found. Comput. Sci.	Abbreviated Journal
	Volume	1	Issue	3	Pages	325-340
	Keywords
	Abstract	Many problems arising in equational theories like Lambda-calculus and Combinatory Logic can be expressed by combinatory equations or systems of equations. However, the solvability problem for an arbitrarily given class of systems is in general undecidable. In this paper we shall focus our attention on a decidable class of systems, which will be called regular systems, and we shall analyse some classical problems and well-known properties of Lambda-calculus that can be described and solved by means of regular systems. The significance of such class will be emphasized showing that for slight extensions of it the solvability problem turns out to be undecidable.
	Address
	Corporate Author				Thesis
	Publisher		Place of Publication		Editor
	Language		Summary Language		Original Title
	Series Editor		Series Title		Abbreviated Series Title
	Series Volume		Series Issue		Edition
	ISSN		ISBN		Medium
	Area		Expedition		Conference
	Notes				Approved	yes
	Call Number	Sapienza @ mari @ ijfcs90			Serial	60
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